Determination of Parabens in Pharmaceutical Formulations by Solid-Phase Microextraction-Ion Mobility Spectrometry
Solid-phase microextraction (SPME) coupled with ion mobility spectrometry (IMS) was used for the detection and quantitation of 4-hydroxybenzoate preservatives, methylparaben, ethylparaben, propylparaben, and butylparaben, in commercial pharmaceutical products. For the first time, SPME-IMS is describ...
Saved in:
Published in | Analytical chemistry (Washington) Vol. 77; no. 18; pp. 5938 - 5946 |
---|---|
Main Authors | , |
Format | Journal Article |
Language | English |
Published |
United States
American Chemical Society
15.09.2005
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Solid-phase microextraction (SPME) coupled with ion mobility spectrometry (IMS) was used for the detection and quantitation of 4-hydroxybenzoate preservatives, methylparaben, ethylparaben, propylparaben, and butylparaben, in commercial pharmaceutical products. For the first time, SPME-IMS is described for the simultaneous detection, separation, and quantitation of multiple analytes in complex matrixes. The parabens are extracted from the samples using SPME, and the analytes on the fiber are heated by the IMS desorber unit and vaporized into the drift tube. The four preservatives differing only by a methyl group were separated in less than 18 ms. The analytical procedure was optimized for fiber coating selection, extraction time, sample pH, sample volume, ionic strength, and IMS conditions. Separation characteristics such as resolution, theoretical plates, and drift times of the parabens were also evaluated based on the direct interfacing of SPME to IMS. The conditions were tested using six over-the-counter topical products containing various combinations of preservatives. Analysis of the samples by SPME-IMS using benzyl paraben as an internal standard yields good comparison to an HPLC method, thereby reinforcing the applicability of this technique as a method for routine analysis. Limits of detection were 10 ng/mL for methylparaben and ethylparaben and 5 ng/mL for propylparaben and butylparaben. Good linearity range and reproducibility of less than 8% were obtained. |
---|---|
AbstractList | Solid-phase microextraction (SPME) coupled with ion mobility spectrometry (IMS) was used for the detection and quantitation of 4-hydroxybenzoate preservatives, methylparaben, ethylparaben, propylparaben, and butylparaben, in commercial pharmaceutical products. For the first time, SPME-IMS is described for the simultaneous detection, separation, and quantitation of multiple analytes in complex matrixes. The parabens are extracted from the samples using SPME, and the analytes on the fiber are heated by the IMS desorber unit and vaporized into the drift tube. The four preservatives differing only by a methyl group were separated in less than 18 ms. The analytical procedure was optimized for fiber coating selection, extraction time, sample pH, sample volume, ionic strength, and IMS conditions. Separation characteristics such as resolution, theoretical plates, and drift times of the parabens were also evaluated based on the direct interfacing of SPME to IMS. The conditions were tested using six over-the-counter topical products containing various combinations of preservatives. Analysis of the samples by SPME-IMS using benzyl paraben as an internal standard yields good comparison to an HPLC method, thereby reinforcing the applicability of this technique as a method for routine analysis. Limits of detection were 10 ng/mL for methylparaben and ethylparaben and 5 ng/mL for propylparaben and butylparaben. Good linearity range and reproducibility of less than 8% were obtained. Solid-phase microextraction (SPME) coupled with ion mobility spectrometry (IMS) was used for the detection and quantitation of 4-hydroxybenzoate preservatives, methylparaben, ethylparaben, propylparaben, and butylparaben, in commercial pharmaceutical products. For the first time, SPME-IMS is described for the simultaneous detection, separation, and quantitation of multiple analytes in complex matrixes. The parabens are extracted from the samples using SPME, and the analytes on the fiber are heated by the IMS desorber unit and vaporized into the drift tube. The four preservatives differing only by a methyl group were separated in less than 18 ms. The analytical procedure was optimized for fiber coating selection, extraction time, sample pH, sample volume, ionic strength, and IMS conditions. Separation characteristics such as resolution, theoretical plates, and drift times of the parabens were also evaluated based on the direct interfacing of SPME to IMS. The conditions were tested using six over-the-counter topical products containing various combinations of preservatives. Analysis of the samples by SPME-IMS using benzyl paraben as an internal standard yields good comparison to an HPLC method, thereby reinforcing the applicability of this technique as a method for routine analysis. Limits of detection were 10 ng/mL for methylparaben and ethylparaben and 5 ng/mL for propylparaben and butylparaben. Good linearity range and reproducibility of less than 8% were obtained.[PUBLICATION ABSTRACT] |
Author | Lokhnauth, John K Snow, Nicholas H |
Author_xml | – sequence: 1 givenname: John K surname: Lokhnauth fullname: Lokhnauth, John K – sequence: 2 givenname: Nicholas H surname: Snow fullname: Snow, Nicholas H |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/16159125$$D View this record in MEDLINE/PubMed |
BookMark | eNpl0U1P3DAQBmCrApWF9sAfqKJKrdRDwGPHdvZYsaVFfHQl4Gw5zkQ1JPFiOxL77-vtrkCiJx_m0TvjmUOyN_oRCTkGegKUwamxVNCKAn9HZiAYLWVdsz0yo5TykilKD8hhjA-UAlCQ78kBSBBzYGJGnhaYMAxuNMn5sfBdsTTBNDjGwo3F8o8Jg7E4JWdNX5z7MEz9PxmLZl3c-t61ZUYRi2tng8fnFIzd1MuLnHbtG9e7lOEKbQp-wBTWH8h-Z_qIH3fvEbk__3F39qu8-v3z4uz7VWm4qlOpeNNS6KwQsgLLOtp1TIqKgxKqM9ZaY_m8tZUAxltUSlhBaxAI0laGVcCPyNdt7ir4pwlj0oOLFvvejOinqGUt8mbkBn5-Ax_8FMY8m2agallXc57Rty3Kv4wxYKdXwQ0mrDVQvTmCfjlCtp92gVMzYPsqd1vPoNwCFxM-v9RNeNRScSX03fJWL2smby4XN3qR_ZetNza-Dvd_47-XVp6Q |
CODEN | ANCHAM |
CitedBy_id | crossref_primary_10_1016_j_msec_2013_11_021 crossref_primary_10_18596_jotcsa_403497 crossref_primary_10_1002_jssc_201300436 crossref_primary_10_1016_j_jpba_2009_08_016 crossref_primary_10_1039_C5NJ03652F crossref_primary_10_1080_05704920600663469 crossref_primary_10_1016_j_molliq_2015_12_079 crossref_primary_10_1093_chromsci_bmv011 crossref_primary_10_1016_j_aca_2018_03_059 crossref_primary_10_3390_s141120963 crossref_primary_10_1016_j_matpr_2019_11_217 crossref_primary_10_1016_j_aca_2006_08_049 crossref_primary_10_1002_jms_952 crossref_primary_10_1016_j_chroma_2007_08_062 crossref_primary_10_1021_ie301890b crossref_primary_10_1016_j_talanta_2011_01_067 crossref_primary_10_1016_j_saa_2013_11_072 crossref_primary_10_1016_j_jasms_2008_10_002 crossref_primary_10_1556_AChrom_24_2012_4_6 crossref_primary_10_1007_s12127_017_0216_9 crossref_primary_10_1016_j_chroma_2009_11_005 crossref_primary_10_1039_c3ay00025g crossref_primary_10_1002_elan_201000042 crossref_primary_10_1365_s10337_010_1646_2 crossref_primary_10_1007_s12127_018_0239_x crossref_primary_10_1016_j_trac_2007_10_014 crossref_primary_10_1007_s12127_012_0103_3 crossref_primary_10_1016_j_chroma_2008_10_105 crossref_primary_10_1002_elsc_200720221 crossref_primary_10_1002_jssc_202100917 crossref_primary_10_1021_acs_analchem_0c01318 crossref_primary_10_1016_j_chroma_2007_05_089 crossref_primary_10_1039_C6RA24225A crossref_primary_10_1016_j_envint_2019_05_084 crossref_primary_10_1016_j_talanta_2011_01_075 crossref_primary_10_1016_j_microc_2018_02_032 crossref_primary_10_1016_j_chroma_2018_05_001 crossref_primary_10_1080_00032719_2020_1870232 crossref_primary_10_1021_acs_analchem_5b01585 crossref_primary_10_1007_s40242_014_3566_4 crossref_primary_10_1016_j_aca_2012_09_014 crossref_primary_10_1016_j_jchromb_2015_07_020 crossref_primary_10_1002_jssc_200800635 crossref_primary_10_1007_s00216_006_0728_3 crossref_primary_10_1016_j_chroma_2014_02_075 crossref_primary_10_1007_s10337_019_03691_3 crossref_primary_10_1021_ac5007393 crossref_primary_10_1021_ac061896e crossref_primary_10_1007_s00216_006_0631_y crossref_primary_10_1016_j_chroma_2006_03_045 crossref_primary_10_1016_j_etap_2020_103495 crossref_primary_10_1039_B612796G crossref_primary_10_1016_j_envres_2015_07_014 crossref_primary_10_1134_S1061934821050051 crossref_primary_10_3390_ijms141224531 crossref_primary_10_1016_j_talanta_2010_02_035 crossref_primary_10_1016_j_chroma_2009_05_071 crossref_primary_10_1016_j_talanta_2016_08_009 crossref_primary_10_1080_01496395_2012_756034 crossref_primary_10_1016_j_chroma_2014_06_094 crossref_primary_10_1016_j_scitotenv_2013_04_097 crossref_primary_10_1002_jssc_201000024 crossref_primary_10_1002_jssc_201500484 crossref_primary_10_1016_j_jpba_2020_113582 crossref_primary_10_1021_acs_jpca_0c00118 crossref_primary_10_1016_j_chroma_2009_04_025 crossref_primary_10_1016_j_chroma_2005_09_045 crossref_primary_10_1007_s00604_017_2577_5 crossref_primary_10_1002_elps_200700916 crossref_primary_10_1016_j_jhazmat_2007_12_022 crossref_primary_10_1016_j_talanta_2019_120541 crossref_primary_10_1039_C9AY01147A crossref_primary_10_1134_S2070205119040221 |
Cites_doi | 10.1002/(SICI)1520-667X(1998)10:7<551::AID-MCS1>3.0.CO;2-F 10.1021/ac011296+ 10.1021/ac50007a011 10.1021/ac00182a009 10.1002/(SICI)1520-667X(2000)12:3<172::AID-MCS7>3.0.CO;2-W 10.1016/S0731-7085(98)00173-3 10.1021/es025986m 10.1080/00032719708007229 10.1021/ja00193a010 10.1002/mcs.1011 10.1016/S0021-9673(03)00395-9 10.1016/S1570-0232(03)00047-3 10.1039/b204701b 10.1016/S0731-7085(96)01914-0 10.1016/S0045-6535(02)00868-8 10.1016/S0731-7085(00)00358-7 10.1016/S0003-2670(98)00563-7 10.1021/ac00218a019 10.1016/S0003-2670(02)00375-6 10.1016/0731-7085(96)01777-3 10.1006/taap.1998.8544 10.1002/jssc.200401924 |
ContentType | Journal Article |
Copyright | Copyright © 2005 American Chemical Society Copyright American Chemical Society Sep 15, 2005 |
Copyright_xml | – notice: Copyright © 2005 American Chemical Society – notice: Copyright American Chemical Society Sep 15, 2005 |
DBID | BSCLL CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QF 7QO 7QQ 7SC 7SE 7SP 7SR 7TA 7TB 7TM 7U5 7U7 7U9 8BQ 8FD C1K F28 FR3 H8D H8G H94 JG9 JQ2 KR7 L7M L~C L~D P64 7X8 |
DOI | 10.1021/ac0504013 |
DatabaseName | Istex Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Aluminium Industry Abstracts Biotechnology Research Abstracts Ceramic Abstracts Computer and Information Systems Abstracts Corrosion Abstracts Electronics & Communications Abstracts Engineered Materials Abstracts Materials Business File Mechanical & Transportation Engineering Abstracts Nucleic Acids Abstracts Solid State and Superconductivity Abstracts Toxicology Abstracts Virology and AIDS Abstracts METADEX Technology Research Database Environmental Sciences and Pollution Management ANTE: Abstracts in New Technology & Engineering Engineering Research Database Aerospace Database Copper Technical Reference Library AIDS and Cancer Research Abstracts Materials Research Database ProQuest Computer Science Collection Civil Engineering Abstracts Advanced Technologies Database with Aerospace Computer and Information Systems Abstracts Academic Computer and Information Systems Abstracts Professional Biotechnology and BioEngineering Abstracts MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Materials Research Database Technology Research Database Computer and Information Systems Abstracts – Academic Mechanical & Transportation Engineering Abstracts Nucleic Acids Abstracts ProQuest Computer Science Collection Computer and Information Systems Abstracts Materials Business File Environmental Sciences and Pollution Management Aerospace Database Copper Technical Reference Library Engineered Materials Abstracts Biotechnology Research Abstracts AIDS and Cancer Research Abstracts Advanced Technologies Database with Aerospace ANTE: Abstracts in New Technology & Engineering Civil Engineering Abstracts Aluminium Industry Abstracts Virology and AIDS Abstracts Toxicology Abstracts Electronics & Communications Abstracts Ceramic Abstracts METADEX Biotechnology and BioEngineering Abstracts Computer and Information Systems Abstracts Professional Solid State and Superconductivity Abstracts Engineering Research Database Corrosion Abstracts MEDLINE - Academic |
DatabaseTitleList | MEDLINE - Academic Materials Research Database MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Engineering Chemistry |
EISSN | 1520-6882 |
EndPage | 5946 |
ExternalDocumentID | 902263581 10_1021_ac0504013 16159125 ark_67375_TPS_P826NKDN_D c474875311 |
Genre | Journal Article |
GroupedDBID | - .K2 02 186 1AW 23M 3O- 4.4 53G 53T 55A 5GY 5RE 5VS 7~N 85S AABXI AAUTI ABDEX ABFLS ABMVS ABOCM ABPPZ ABPTK ABUCX ABUFD ACGFS ACGOD ACIWK ACJ ACNCT ACPRK ACPVT ACS AEESW AENEX AETEA AFEFF AFFDN AFFNX AFMIJ AFRAH AIDAL ALMA_UNASSIGNED_HOLDINGS ANTXH AQSVZ BAANH BKOMP CS3 D0L DZ EBS ED ED~ EJD F20 F5P GJ GNL IH9 IHE JG JG~ K2 LG6 NHB OHM OHT P2P PQEST PQQKQ ROL RXW TAE TAF TN5 UHB UI2 UKR UNC UQL VF5 VG9 VOH VQA W1F WH7 X X6Y XFK YZZ ZCG --- -DZ -~X .DC .GJ 6J9 6TJ ABFRP ABHFT ABHMW ABJNI ABQRX ACBEA ACGFO ACKOT ADHLV AGXLV AHGAQ BSCLL GGK KZ1 XOL XSW ZCA ~02 AAHBH CGR CUPRZ CUY CVF ECM EIF NPM AAYXX CITATION 7QF 7QO 7QQ 7SC 7SE 7SP 7SR 7TA 7TB 7TM 7U5 7U7 7U9 8BQ 8FD C1K F28 FR3 H8D H8G H94 JG9 JQ2 KR7 L7M L~C L~D P64 7X8 |
ID | FETCH-LOGICAL-a378t-73bd01fc55641c2f0ff265431757facccac39dc45123de775c50815e16c4a2413 |
IEDL.DBID | ACS |
ISSN | 0003-2700 |
IngestDate | Fri Aug 16 01:15:57 EDT 2024 Thu Oct 10 22:13:45 EDT 2024 Thu Sep 26 17:55:57 EDT 2024 Sat Sep 28 07:50:38 EDT 2024 Wed Jan 17 04:50:34 EST 2024 Thu Aug 27 13:42:59 EDT 2020 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 18 |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-a378t-73bd01fc55641c2f0ff265431757facccac39dc45123de775c50815e16c4a2413 |
Notes | istex:133CFA857668A50F9255745DDAC13B434EA5848D ark:/67375/TPS-P826NKDN-D ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
PMID | 16159125 |
PQID | 217868493 |
PQPubID | 45400 |
PageCount | 9 |
ParticipantIDs | proquest_miscellaneous_68570061 proquest_journals_217868493 crossref_primary_10_1021_ac0504013 pubmed_primary_16159125 istex_primary_ark_67375_TPS_P826NKDN_D acs_journals_10_1021_ac0504013 |
ProviderPackageCode | JG~ 55A AABXI GNL VF5 7~N ACJ VG9 W1F ANTXH ACS AEESW AFEFF .K2 ABMVS ABUCX IH9 BAANH AQSVZ ED~ UI2 |
PublicationCentury | 2000 |
PublicationDate | 2005-09-15 |
PublicationDateYYYYMMDD | 2005-09-15 |
PublicationDate_xml | – month: 09 year: 2005 text: 2005-09-15 day: 15 |
PublicationDecade | 2000 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States – name: Washington |
PublicationTitle | Analytical chemistry (Washington) |
PublicationTitleAlternate | Anal. Chem |
PublicationYear | 2005 |
Publisher | American Chemical Society |
Publisher_xml | – name: American Chemical Society |
References | Thomassin M. (ac0504013b00004/ac0504013b00004_1) 1997; 15 Mejias R. (ac0504013b00016/ac0504013b00016_1) 2003; 995 ac0504013b00027/ac0504013b00027_1 Sottofattori E. (ac0504013b00007/ac0504013b00007_1) 1998; 18 Orzechowska G. (ac0504013b00024/ac0504013b00024_1) 1997 Asbury G. R. (ac0504013b00029/ac0504013b00029_1) 2000; 12 Yu X. (ac0504013b00014/ac0504013b00014_1) 1999; 71 Akhtar M. J. (ac0504013b00006/ac0504013b00006_1) 1996; 14 Mahuxier P. E. (ac0504013b00008/ac0504013b00008_1) 2001; 924 Huang H. (ac0504013b00011/ac0504013b00011_1) 2003; 993 Karaisz K. (ac0504013b00022/ac0504013b00022_1) 2001; 13 Raikos N. (ac0504013b00017/ac0504013b00017_1) 2003; 789 Wang S. (ac0504013b00005/ac0504013b00005_1) 1998; 377 Berant Z. (ac0504013b00030/ac0504013b00030_1) 1989; 111 Karpas Z. (ac0504013b00031/ac0504013b00031_1) 1989; 61 Yuan H. (ac0504013b00019/ac0504013b00019_1) 2001; 73 Dewsbury P. (ac0504013b00015/ac0504013b00015_1) 2003; 37 McCooeye M. (ac0504013b00025/ac0504013b00025_1) 2002; 74 Cantwell F. F. (ac0504013b00003/ac0504013b00003_1) 1976; 48 Zuccarello J. (ac0504013b00020/ac0504013b00020_1) 2003; 51 Harvey P. W. (ac0504013b00002/ac0504013b00002_1) 2003; 23 Labat L. (ac0504013b00010/ac0504013b00010_1) 2000; 23 Orzechowska G. (ac0504013b00023/ac0504013b00023_1) 1997; 30 Gentilli S. (ac0504013b00018/ac0504013b00018_1) 2002; 780 Tong H. (ac0504013b00026/ac0504013b00026_1) 2002; 127 Routledge E. J. (ac0504013b00001/ac0504013b00001_1) 1998; 153 Eiceman G. A. (ac0504013b00028/ac0504013b00028_1) 1994 Baalbaki B. (ac0504013b00009/ac0504013b00009_1) 2002; 463 Okeyo P. (ac0504013b00013/ac0504013b00013_1) 1998; 10 Arthur C. L. (ac0504013b00012/ac0504013b00012_1) 1990; 62 Chen J. (ac0504013b00021/ac0504013b00021_1) 1995; 67 |
References_xml | – volume: 10 start-page: 556 issue: 7 year: 1998 ident: ac0504013b00013/ac0504013b00013_1 publication-title: J. Microcolumn doi: 10.1002/(SICI)1520-667X(1998)10:7<551::AID-MCS1>3.0.CO;2-F contributor: fullname: Okeyo P. – volume: 74 start-page: 3075 year: 2002 ident: ac0504013b00025/ac0504013b00025_1 publication-title: Anal. Chem. doi: 10.1021/ac011296+ contributor: fullname: McCooeye M. – volume: 48 start-page: 1854 year: 1976 ident: ac0504013b00003/ac0504013b00003_1 publication-title: Anal. Chem. doi: 10.1021/ac50007a011 contributor: fullname: Cantwell F. F. – volume: 67 start-page: 2533 year: 1995 ident: ac0504013b00021/ac0504013b00021_1 publication-title: Anal. Chem. contributor: fullname: Chen J. – volume: 61 start-page: 689 year: 1989 ident: ac0504013b00031/ac0504013b00031_1 publication-title: Anal. Chem. doi: 10.1021/ac00182a009 contributor: fullname: Karpas Z. – volume: 12 start-page: 178 year: 2000 ident: ac0504013b00029/ac0504013b00029_1 publication-title: J. Microcolumn doi: 10.1002/(SICI)1520-667X(2000)12:3<172::AID-MCS7>3.0.CO;2-W contributor: fullname: Asbury G. R. – volume: 18 start-page: 213 year: 1998 ident: ac0504013b00007/ac0504013b00007_1 publication-title: J. Pharm. Biomed. Anal. doi: 10.1016/S0731-7085(98)00173-3 contributor: fullname: Sottofattori E. – volume: 37 start-page: 1397 year: 2003 ident: ac0504013b00015/ac0504013b00015_1 publication-title: J. Environ. Sci. Technol. doi: 10.1021/es025986m contributor: fullname: Dewsbury P. – volume-title: Proc. SPIE year: 1997 ident: ac0504013b00024/ac0504013b00024_1 contributor: fullname: Orzechowska G. – volume: 73 start-page: 4416 year: 2001 ident: ac0504013b00019/ac0504013b00019_1 publication-title: Anal. Chem. contributor: fullname: Yuan H. – volume: 30 start-page: 1444 year: 1997 ident: ac0504013b00023/ac0504013b00023_1 publication-title: Anal. Lett. doi: 10.1080/00032719708007229 contributor: fullname: Orzechowska G. – volume: 111 start-page: 3824 year: 1989 ident: ac0504013b00030/ac0504013b00030_1 publication-title: J. Am. Chem. Soc. doi: 10.1021/ja00193a010 contributor: fullname: Berant Z. – volume: 13 start-page: 7 year: 2001 ident: ac0504013b00022/ac0504013b00022_1 publication-title: J. Microcolumn doi: 10.1002/mcs.1011 contributor: fullname: Karaisz K. – volume-title: Ion Mobility Spectrometry year: 1994 ident: ac0504013b00028/ac0504013b00028_1 contributor: fullname: Eiceman G. A. – volume: 993 start-page: 164 year: 2003 ident: ac0504013b00011/ac0504013b00011_1 publication-title: J. Chromatogr., A doi: 10.1016/S0021-9673(03)00395-9 contributor: fullname: Huang H. – volume: 789 start-page: 63 year: 2003 ident: ac0504013b00017/ac0504013b00017_1 publication-title: J. Chromatogr., B doi: 10.1016/S1570-0232(03)00047-3 contributor: fullname: Raikos N. – volume: 127 start-page: 1210 year: 2002 ident: ac0504013b00026/ac0504013b00026_1 publication-title: Analyst doi: 10.1039/b204701b contributor: fullname: Tong H. – volume: 23 start-page: 288 year: 2003 ident: ac0504013b00002/ac0504013b00002_1 publication-title: J. Appl. Toxicol. contributor: fullname: Harvey P. W. – volume: 15 start-page: 838 year: 1997 ident: ac0504013b00004/ac0504013b00004_1 publication-title: J. Pharm. Biomed. Anal. doi: 10.1016/S0731-7085(96)01914-0 contributor: fullname: Thomassin M. – volume: 51 start-page: 810 year: 2003 ident: ac0504013b00020/ac0504013b00020_1 publication-title: Chemosphere doi: 10.1016/S0045-6535(02)00868-8 contributor: fullname: Zuccarello J. – volume: 23 start-page: 779 year: 2000 ident: ac0504013b00010/ac0504013b00010_1 publication-title: J. Pharm. Biomed. Anal. doi: 10.1016/S0731-7085(00)00358-7 contributor: fullname: Labat L. – volume: 995 start-page: 20 year: 2003 ident: ac0504013b00016/ac0504013b00016_1 publication-title: J. Chromatogr., A contributor: fullname: Mejias R. – volume: 377 start-page: 93 year: 1998 ident: ac0504013b00005/ac0504013b00005_1 publication-title: Anal. Chim. Acta doi: 10.1016/S0003-2670(98)00563-7 contributor: fullname: Wang S. – volume: 62 start-page: 2145 year: 1990 ident: ac0504013b00012/ac0504013b00012_1 publication-title: Anal. Chem. doi: 10.1021/ac00218a019 contributor: fullname: Arthur C. L. – volume: 71 start-page: 3002 year: 1999 ident: ac0504013b00014/ac0504013b00014_1 publication-title: Anal. Chem. contributor: fullname: Yu X. – volume: 463 start-page: 20 year: 2002 ident: ac0504013b00009/ac0504013b00009_1 publication-title: Anal. Chim. Acta doi: 10.1016/S0003-2670(02)00375-6 contributor: fullname: Baalbaki B. – volume: 14 start-page: 1613 year: 1996 ident: ac0504013b00006/ac0504013b00006_1 publication-title: J. Pharm. Biomed. Anal. doi: 10.1016/0731-7085(96)01777-3 contributor: fullname: Akhtar M. J. – volume: 780 start-page: 192 year: 2002 ident: ac0504013b00018/ac0504013b00018_1 publication-title: J. Chromatogr., B contributor: fullname: Gentilli S. – volume: 924 start-page: 470 year: 2001 ident: ac0504013b00008/ac0504013b00008_1 publication-title: J. Chromatogr., A contributor: fullname: Mahuxier P. E. – volume: 153 start-page: 19 year: 1998 ident: ac0504013b00001/ac0504013b00001_1 publication-title: Toxicol. Appl. Pharmacol. doi: 10.1006/taap.1998.8544 contributor: fullname: Routledge E. J. – ident: ac0504013b00027/ac0504013b00027_1 doi: 10.1002/jssc.200401924 |
SSID | ssj0011016 |
Score | 2.1957788 |
Snippet | Solid-phase microextraction (SPME) coupled with ion mobility spectrometry (IMS) was used for the detection and quantitation of 4-hydroxybenzoate preservatives,... |
SourceID | proquest crossref pubmed istex acs |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 5938 |
SubjectTerms | Analytical chemistry Calibration Chromatography, High Pressure Liquid Hydrogen-Ion Concentration Ions - chemistry Mass spectrometry Parabens - chemistry Pharmacology Solid Phase Microextraction - instrumentation Solid Phase Microextraction - methods Spectrum Analysis |
Title | Determination of Parabens in Pharmaceutical Formulations by Solid-Phase Microextraction-Ion Mobility Spectrometry |
URI | http://dx.doi.org/10.1021/ac0504013 https://api.istex.fr/ark:/67375/TPS-P826NKDN-D/fulltext.pdf https://www.ncbi.nlm.nih.gov/pubmed/16159125 https://www.proquest.com/docview/217868493 https://search.proquest.com/docview/68570061 |
Volume | 77 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV3fb9MwED6N7QH2MGDAKINhAeIto3ZiO32cWqoBalWpm7S3yHFsbRoko2mlbX89d07TFcHgORfH8V3i73w_PoAPovDcmhBTp6MbldsIXTAeqSI2PvZprgXVDo_G6vg0-Xomzzbg_T0RfME_GduVXfICHsCWwP2QPKyj_nQVKiD3s6XFoyhq2z5o_Vbaemz929azRat4fT-uDPvL8DEM2iqdJq3k8nAxzw_t7Z9NG_819Sews8SX7KgxiKew4cpdeNhvad12YXutA-Ez-Dlo02FIQazybGJmJkffll2UbHK-fuDNhohvl2xfNctv2LT6flFEKFQ7NqLEPvzRz5pCiegLjjaqQuYtCl4Frp0fDmfwHE6Hn0_6x9GShSEysU7nkY7zosu9lVIl3Arf9V5QQSriDu2NRQuwca-wCSKHuHBaS4uYj0vHlU0MRe1ewGZZle4lMJ0bq3tp4gU1avOe2EGVU4mzSmgvXQcOUE3Z8iuqsxAgFzxbrWMH3rUazK6abhx_E_oYdLuSMLNLSl_TMjuZTLMJOlTjb4NxNujAfqv8u2eii5aqNOnhMG9XV1FFFEcxpasWdaYCKYDiHdhrLOZuLogPewgZX_3vRfbhUegBS1wU8jVszmcL9wbRzTw_CNb9C48R8TM |
link.rule.ids | 315,786,790,2782,27107,27955,27956,57091,57141 |
linkProvider | American Chemical Society |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwED_B9jD2wMeAUQabhRBv2ZoP2-kjaqk6tlaV2kl7sxzHFtMgGU0rAX89d07SFgSC51yci-8S_853vh_A2yh3odE-p05bNyIzAYZgYSDyWLvYpZmM6OzweCJGV8nHa37dtMmhszCoRIUjVT6Jv-kuEJ5p0-VdCgbuwy6XuMoRDOrP1hkDikJbdjxKprZdhLZvpRXIVL-sQLs0md_-Di_9MjN8VPMVeQV9dcnt6WqZnZofv_Vu_L83eAwPG7TJ3tfu8QTu2eIA9votydsB7G_1I3wKXwdtcQyZi5WOTfVCZxjpspuCTT9tb3-zIaLdhvurYtl3Nis_3-QBClWWjanMD3_7i_rYRHCOo41LX4eLgneeeeeLRQ2ewdXww7w_ChpOhkDHMl0GMs7ybugM5yIJTeS6zkV0PBVRiHTaoD-YuJebBHFEnFspuUEEGHIbCpNoyuE9h52iLOwLYDLTRvbSxEXUts054goVViTWiEg6bjtwjNOomm-qUj5dHoVqPY8deNMaUt3VvTn-JPTOm3gtoRe3VMwmuZpPZ2qK4dXkYjBRgw4ctT6weSYGbKlIkx4Oc7K-iiairIoubLmqlPAUASLswGHtOBtdEC32EEC-_NeLnMDeaD6-VJfnk4sjeOC7wxJLBX8FO8vFyr5G3LPMjr3D_wQ0pfme |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwED_BJsF44GN8lcFmIcRbRp3Edvo4tVQboyVSN2lvkePYYtpIStNKwF_PnZtkBYHgORfn7DvHv_N9AbwJC8eN9j51urqRuQnQBOOBLCLtIpfkKqTc4clUHp_HHy7ERWMoUi4MMlHjSLV34tOunheuqTDA32nTF30yCG7DtlA8po14NJx1XgOyRNsOeeRQbSsJbb5Kp5CpfzmFtmlBv_0dYvqjZvwAPnVM-giTq8PVMj80P36r3_j_s3gI9xvUyY7WavIIbtlyF-4O22Zvu3Bvoy7hY_g6aoNkSGyscizVC52jxcsuS5Z-3rwGZ2NEvU0PsJrl39msur4sAiSqLZtQuB_-_hfr9IngBEebVD4eFwnnvgPPF4scPIHz8fuz4XHQ9GYIdKSSZaCivOhzZ4SQMTeh6zsXUpoqohHltEG9MNGgMDHiiaiwSgmDSJALy6WJNfnynsJWWZX2OTCVa6MGSexCKt_mHPUMlVbG1shQOWF7sI9LmTV7q8682zzkWbeOPXjdCjObr2t0_InorRdzR6EXVxTUpkR2ls6yFM2s6elomo16sNfqwc030XBLZBIPcJiD7imKiLwrurTVqs6kbxUgeQ-erZXnhhdEjQMEki_-NZEDuJOOxtnHk-npHuz4IrHUrEK8hK3lYmVfIfxZ5vte538CTyD8GA |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Determination+of+Parabens+in+Pharmaceutical+Formulations+by+Solid-Phase+Microextraction-Ion+Mobility+Spectrometry&rft.jtitle=Analytical+chemistry+%28Washington%29&rft.au=Lokhnauth%2C+John+K&rft.au=Snow%2C+Nicholas+H&rft.date=2005-09-15&rft.pub=American+Chemical+Society&rft.issn=0003-2700&rft.eissn=1520-6882&rft.volume=77&rft.issue=18&rft.spage=5938&rft.epage=5946&rft_id=info:doi/10.1021%2Fac0504013&rft.externalDocID=c474875311 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0003-2700&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0003-2700&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0003-2700&client=summon |