Standard E TB-Feron ELISA and Standard F TB-Feron FIA positivity rates and agreement with QuantiFERON-TB Gold Plus among TB high-risk population in Bandung, Indonesia

This study evaluates the performance of two alternative interferon-gamma release assays, Standard E TB-Feron enzyme-linked immunosorbent assay and Standard F TB-Feron fluorescent immunoassay, for diagnosing tuberculosis infection (TBI) among high-risk populations in Bandung, Indonesia. Both assays d...

Full description

Saved in:
Bibliographic Details
Published inJournal of clinical microbiology Vol. 63; no. 4; p. e0148624
Main Authors Turbawaty, Dewi Kartika, Maulida, Syifa Nur, Anadhea, Darin Rizka, Ritonga, Mulyanusa Amarullah, Andriyoko, Basti, Wisaksana, Rudi, Indrati, Agnes Rengga, Mulyani Soetedjo, Nanny Natalia, Hamijoyo, Laniyati, Koesoemadinata, Raspati Cundarani, Alisjahbana, Bachti, Parwati, Ida
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 09.04.2025
Subjects
Adolescent
Adult
Aged
Clinical Microbiology
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay - methods
Female
Humans
Indonesia - epidemiology
Interferon-gamma Release Tests - methods
Male
Middle Aged
Mycobacteriology and Aerobic Actinomycetes
Mycobacterium tuberculosis - immunology
Mycobacterium tuberculosis - isolation & purification
Sensitivity and Specificity
Sputum - microbiology
Tuberculosis - diagnosis
Tuberculosis - epidemiology
Young Adult
Indonesia
diagnostic performance
Mycobacterium tuberculosis
immunology
TB infection
Online AccessGet full text

Cover

More Information
Summary:This study evaluates the performance of two alternative interferon-gamma release assays, Standard E TB-Feron enzyme-linked immunosorbent assay and Standard F TB-Feron fluorescent immunoassay, for diagnosing tuberculosis infection (TBI) among high-risk populations in Bandung, Indonesia. Both assays demonstrated comparable clinical performance to the widely used QuantiFERON-TB Gold Plus (QFT-Plus). Given the global burden of tuberculosis, particularly in resource-limited settings, these findings suggest that the TB-Feron assays could serve as reliable alternatives to QFT-Plus for TBI detection. This research highlights the potential for these assays to improve tuberculosis diagnosis, offering a more accessible and efficient screening tool, especially for high-risk populations, and supporting broader tuberculosis surveillance.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
The authors declare no conflict of interest.
ISSN:0095-1137
1098-660X
1098-660X
DOI:10.1128/jcm.01486-24