Cell Internalizable and Intracellularly Degradable Cationic Polyurethane Micelles as a Potential Platform for Efficient Imaging and Drug Delivery

• Published in: Biomacromolecules Vol. 15; no. 8; pp. 2896 - 2906
• Main Authors: Ding, Mingming, Zeng, Xin, He, Xueling, Li, Jiehua, Tan, Hong, Fu, Qiang
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 11.08.2014
• Subjects: ammonium; Animals; antineoplastic agents; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Applied sciences; Biological and medical sciences; Cell Line, Tumor; Contrast Media - chemistry; Contrast Media - pharmacology; Drug Carriers - chemistry; Drug Carriers - pharmacology; Exact sciences and technology; Ferric Compounds - chemistry; Ferric Compounds - pharmacology; General pharmacology; glutathione; image analysis; iron oxides; Magnetic Resonance Imaging; Male; Medical sciences; Mice; Mice, Inbred ICR; Micelles; monitoring; nanocarriers; nanoparticles; neoplasm cells; Organic polymers; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Physicochemistry of polymers; Polymers with particular properties; polyurethanes; Polyurethanes - chemistry; Polyurethanes - pharmacology; Preparation, kinetics, thermodynamics, mechanism and catalysts; Iron oxide; Molecular structure; Nanoparticle; Quaternary ammonium copolymer; Drug carrier; Nanoencapsulation; Polyaddition; Chemical reduction; Organic disulfide; Magnetite; Spin spin relaxation; Tumor cell; Magnetic properties; Amphiphilic polymer; Control release polymer; Chemical degradation; Intracellular space; Experimental study; Dimension spectrum; Urethane copolymer; Sulfur copolymer; Nuclear magnetic resonance imaging; In vitro; Functional polymer; Theranostics; Magnetization curve; Magnetic particles; Multiblock copolymer; Internalization; Preparation; Aqueous solution; Micellar solution

A cell internalizable and intracellularly degradable micellar system, assembled from multiblock polyurethanes bearing cell-penetrating gemini quaternary ammonium pendent groups in the side chain and redox-responsive disulfide linkages throughout the backbone, was developed for potential magnetic res...