Fine-Tuning Monophosphine Ligands for Enhanced Enantioselectivity. Influence of Chiral Hemilabile Pendant Groups

• Published in: Organic letters Vol. 6; no. 9; pp. 1515 - 1517
• Main Authors: Zhang, Aibin, RajanBabu, T. V
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 29.04.2004; Amer Chemical Soc
• Subjects: Catalysis; Chemistry; Chemistry, Organic; Ligands; Molecular Conformation; Nickel - chemistry; Phosphines - chemical synthesis; Phosphines - chemistry; Physical Sciences; Science & Technology; Stereoisomerism; Styrenes - chemical synthesis; ASYMMETRIC CATALYSIS; HYDROVINYLATION REACTIONS; HYDROGENATION; CONJUGATE ADDITION

C 2 -Symmetric P-(2-X-aryl)-2,5-dialkylphospholanes (X = dioxolan-2-yl or dioxan-2-yl), designed on the basis of a working model for asymmetric induction, are effective ligands for the Ni(II)-catalyzed asymmetric hydrovinylation of styrenes. Excellent yields (>99%), selectivities for the desired...