A Practical Method for Oxazole Synthesis by Cycloisomerization of Propargyl Amides

2,5-Disubstituted and 2,4,5-trisubstituted oxazol-5-yl carbonyl compounds were prepared in good yields by a mild SiO2-mediated cycloisomerization of propargyl amides.

Saved in:
Bibliographic Details
Published inOrganic letters Vol. 6; no. 20; pp. 3593 - 3595
Main Authors Wipf, Peter, Aoyama, Yasunori, Benedum, Tyler E
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 30.09.2004
Amer Chemical Soc
Subjects
Amides - chemistry
Catalysis
Chemistry
Chemistry, Organic
Combinatorial Chemistry Techniques
Cyclization
Oxazoles - chemical synthesis
Physical Sciences
Science & Technology
Silicon Dioxide - chemistry
Stereoisomerism
FURANS
MECHANISM
PRODUCT
ISOMERIZATION
DIAZONAMIDE
ALKYNYL ALLYLIC ALCOHOLS
ENANTIOMER
Online AccessGet full text

Cover

More Information
Summary:2,5-Disubstituted and 2,4,5-trisubstituted oxazol-5-yl carbonyl compounds were prepared in good yields by a mild SiO2-mediated cycloisomerization of propargyl amides.
Bibliography:Medline
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0485058