Third intracellular loop of HCMV US28 is necessary for signaling and viral reactivation

• Published in: Journal of virology Vol. 99; no. 1; p. e0180124
• Main Authors: Medica, Samuel, Denton, Michael, Diggins, Nicole L., Kramer-Hansen, Olivia, Crawford, Lindsey B., Mayo, Adam T., Perez, Wilma D., Daily, Michael A., Parkins, Christopher J., Slind, Luke E., Pung, Lydia J., Weber, Whitney C., Jaeger, Hannah K., Streblow, Zachary J., Sulgey, Gauthami, Kreklywich, Craig N., Alexander, Timothy, Rosenkilde, Mette M., Caposio, Patrizia, Hancock, Meaghan H., Streblow, Daniel N.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 31.01.2025
• Subjects: Animals; Cytomegalovirus - genetics; Cytomegalovirus - physiology; Cytomegalovirus Infections - metabolism; Cytomegalovirus Infections - virology; Humans; Mice; Mutation; Pathogenesis and Immunity; Receptors, Chemokine - chemistry; Receptors, Chemokine - genetics; Receptors, Chemokine - metabolism; Signal Transduction; Viral Proteins - chemistry; Viral Proteins - genetics; Viral Proteins - metabolism; Virology; Virus Activation; Virus Latency; reactivation; cytomegalovirus; signal transduction; G-protein-coupled receptor; latency

Human cytomegalovirus (HCMV) is a β-herpesvirus that infects between 44% and 100% of the world population. Primary infection is typically asymptomatic and results in the establishment of latent infection within CD34 + hematopoietic progenitor cells (HPCs). However, reactivation from latent infection...