Polyethylene Glycol Immunogenicity: Theoretical, Clinical, and Practical Aspects of Anti-Polyethylene Glycol Antibodies

• Published in: ACS nano Vol. 15; no. 9; pp. 14022 - 14048
• Main Authors: Chen, Bing-Mae, Cheng, Tian-Lu, Roffler, Steve R
• Format: Journal Article
• Language: English
• Published: American Chemical Society 28.09.2021
• Subjects: polyethylene glycol; thymus-independent type-2 (TI-2) antigen; humoral immunity; anti-PEG antibodies; pegylation; accelerated blood clearance; SARS-CoV-2 RNA vaccines; pre-existing antibodies; lipo­somes; immunogenicity
• ISSN: 1936-0851; 1936-086X; 1936-086X
• DOI: 10.1021/acsnano.1c05922

Polyethylene glycol (PEG) is a flexible, hydrophilic simple polymer that is physically attached to peptides, proteins, nucleic acids, lipo­somes, and nanoparticles to reduce renal clearance, block antibody and protein binding sites, and enhance the half-life and efficacy of therapeutic molecules. So...