Association of Glutamate Infusion With Risk of Acute Kidney Injury After Coronary Artery Bypass Surgery: A Pooled Analysis of 2 Randomized Clinical Trials

• Published in: JAMA network open Vol. 7; no. 1; p. e2351743
• Main Authors: Holm, Jonas, Vanky, Farkas, Svedjeholm, Rolf
• Format: Journal Article
• Language: English
• Published: United States American Medical Association 02.01.2024
• Subjects: Acute Kidney Injury - epidemiology; Acute Kidney Injury - etiology; Acute Kidney Injury - prevention & control; Aged; Animals; Coronary Artery Bypass - adverse effects; Diabetes Mellitus; Female; Glutamic Acid; Humans; Online Only; Original Investigation; Prospective Studies; Randomized Controlled Trials as Topic; Renal Dialysis; Stroke Volume; Surgery; Ventricular Function, Left

Acute kidney injury (AKI) after cardiac surgery is associated with increased morbidity and mortality, and measures to prevent AKI have had limited success. Glutamate has been reported to enhance natural postischemic recovery of the heart, but not among animals and humans with diabetes. To summarize...