Electrospun Piezoelectric Scaffold with External Mechanical Stimulation for Promoting Regeneration of Peripheral Nerve Injury

• Published in: Biomacromolecules Vol. 24; no. 7; pp. 3268 - 3282
• Main Authors: Zhang, Haiqiang, Lan, Dongwei, Wu, Baiqing, Chen, Xiang, Li, Xia, Li, Zhi, Dai, Fangyin
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 10.07.2023
• Subjects: Animals; antibacterial properties; axons; electric potential difference; electrical treatment; myelination; Nerve Regeneration; nerve tissue; Peripheral Nerve Injuries - therapy; Rats; Rats, Sprague-Dawley; Sciatic Nerve - physiology; silk; Tissue Scaffolds; ultrasonic treatment

Safe and efficient provision of electrical stimulation (ES) for nerve repair and regeneration is a problem that needs to be addressed. In this study, a silk fibroin/poly­(vinylidene fluoride-co-hexafluoropropylene)/Ti3C2T x (SF/PVDF-HFP/MXene) composite scaffold with piezoelectricity was developed b...