In Vitro Toxicity Evaluation of Lignin-(Un)coated Cellulose Based Nanomaterials on Human A549 and THP‑1 Cells

A significant amount of research toward commercial development of cellulose based nanomaterials (CNM) is now in progress with some potential applications. Using human A549 and THP-1 cells, we evaluated the biological responses of various CNMs, made out of similar material but with functional and mor...

Full description

Saved in:
Bibliographic Details
Published inBiomacromolecules Vol. 17; no. 11; pp. 3464 - 3473
Main Authors Yanamala, Naveena, Kisin, Elena R, Menas, Autumn L, Farcas, Mariana T, Khaliullin, Timur O, Vogel, Ulla B, Shurin, Galina V, Schwegler-Berry, Diane, Fournier, Philip M, Star, Alexander, Shvedova, Anna A
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 14.11.2016
Subjects
A549 Cells
cellulose
Cellulose - adverse effects
Cellulose - chemistry
Cellulose - pharmacology
cytotoxicity
Humans
inflammation
Lignin - adverse effects
Lignin - chemistry
Lignin - pharmacology
nanomaterials
Nanostructures - adverse effects
Nanostructures - chemistry
Online AccessGet full text

Cover

Abstract A significant amount of research toward commercial development of cellulose based nanomaterials (CNM) is now in progress with some potential applications. Using human A549 and THP-1 cells, we evaluated the biological responses of various CNMs, made out of similar material but with functional and morphological variations. While A549 cells displayed minimal or no cytotoxic responses following exposure to CNMs, THP-1 cells were more susceptible to cytotoxicity, cellular damage and inflammatory responses. Further analysis of these biological responses evaluated using hierarchical clustering approaches was effective in discriminating (dis)-similarities of various CNMs studied and identified potential inflammatory factors contributing to cytotoxicity. No correlation between cytotoxicity and surface properties of CNMs was found. This study clearly highlights that, in addition to the source and characteristics of CNMs, cell type-specific differences in the recognition/uptake of CNMs along with their inherent capability to respond to external stimuli are crucial for assessing the toxicity of CNMs.
AbstractList A significant amount of research toward commercial development of cellulose based nanomaterials (CNM) is now in progress with some potential applications. Using human A549 and THP-1 cells, we evaluated the biological responses of various CNMs, made out of similar material but with functional and morphological variations. While A549 cells displayed minimal or no cytotoxic responses following exposure to CNMs, THP-1 cells were more susceptible to cytotoxicity, cellular damage and inflammatory responses. Further analysis of these biological responses evaluated using hierarchical clustering approaches was effective in discriminating (dis)-similarities of various CNMs studied and identified potential inflammatory factors contributing to cytotoxicity. No correlation between cytotoxicity and surface properties of CNMs was found. This study clearly highlights that, in addition to the source and characteristics of CNMs, cell type-specific differences in the recognition/uptake of CNMs along with their inherent capability to respond to external stimuli are crucial for assessing the toxicity of CNMs.
Author Kisin, Elena R
Shurin, Galina V
Vogel, Ulla B
Star, Alexander
Fournier, Philip M
Shvedova, Anna A
Khaliullin, Timur O
Farcas, Mariana T
Yanamala, Naveena
Menas, Autumn L
Schwegler-Berry, Diane
AuthorAffiliation Department of Chemistry
University of Pittsburgh Medical Center
Department of Pathology
University of Pittsburgh
National Research Centre for the Working Environment
Department of Physiology and Pharmacology
West Virginia University
AuthorAffiliation_xml – name: Department of Pathology
– name: Department of Chemistry
– name: National Research Centre for the Working Environment
– name: West Virginia University
– name: Department of Physiology and Pharmacology
– name: University of Pittsburgh Medical Center
– name: University of Pittsburgh
Author_xml – sequence: 1
  givenname: Naveena
  surname: Yanamala
  fullname: Yanamala, Naveena
– sequence: 2
  givenname: Elena R
  surname: Kisin
  fullname: Kisin, Elena R
– sequence: 3
  givenname: Autumn L
  surname: Menas
  fullname: Menas, Autumn L
– sequence: 4
  givenname: Mariana T
  surname: Farcas
  fullname: Farcas, Mariana T
– sequence: 5
  givenname: Timur O
  surname: Khaliullin
  fullname: Khaliullin, Timur O
– sequence: 6
  givenname: Ulla B
  surname: Vogel
  fullname: Vogel, Ulla B
– sequence: 7
  givenname: Galina V
  surname: Shurin
  fullname: Shurin, Galina V
– sequence: 8
  givenname: Diane
  surname: Schwegler-Berry
  fullname: Schwegler-Berry, Diane
– sequence: 9
  givenname: Philip M
  surname: Fournier
  fullname: Fournier, Philip M
– sequence: 10
  givenname: Alexander
  surname: Star
  fullname: Star, Alexander
– sequence: 11
  givenname: Anna A
  surname: Shvedova
  fullname: Shvedova, Anna A
  email: ats1@cdc.gov
BackLink https://www.ncbi.nlm.nih.gov/pubmed/27709894$$D View this record in MEDLINE/PubMed
BookMark eNp9kctO3DAUhi0EYri9QBeVl3SRqe3E43hJR9BBGhUWA9voxJfKo8SmdoLKrq_QV-RJ6rnQBQs2vsjfZx39_yk69MEbhD5RMqWE0a-g0rR1oQc1nbWECD47QCeUs1lRzQg73J55IYQUE3Sa0poQIsuKH6MJE4LIWlYnKNx6_OiGGPAq_HbKDS_4-hm6EQYXPA4WL91P73xx-eC_qACD0Xhuum7sQjL4G6R8_wE-zzCY6KBLOFuLsQePr3glMXiNV4v71z9_6dZL5-jIZsxc7Pcz9HBzvZoviuXd99v51bKAUvChaCUTXEkjbF2VTNGatKUgpTREaKOFFkobUoE1LbGWtBq4pXlRoDUDK2h5hi53_z7F8Gs0aWh6l1SeALwJY2pYDoOzWtYb9PMeHdve6OYpuh7iS_MWUgbYDlAxpBSN_Y9Q0myaaHITza6JZt9Elup3Ug53m-oQwXUfq9OdunlbhzH6nNRHwj-PKqHj
CitedBy_id crossref_primary_10_1016_j_eurpolymj_2019_04_021
crossref_primary_10_3390_nano11020389
crossref_primary_10_1021_acssuschemeng_7b00646
crossref_primary_10_1016_j_addma_2023_103711
crossref_primary_10_3390_nano12091432
crossref_primary_10_26599_PBM_2023_9260008
crossref_primary_10_1007_s10570_024_06238_4
crossref_primary_10_1080_08958378_2020_1770901
crossref_primary_10_1016_j_tiv_2023_105616
crossref_primary_10_3390_ma16124447
crossref_primary_10_3389_fimmu_2023_1111123
crossref_primary_10_1039_C9MH01727E
crossref_primary_10_1007_s10570_020_03176_9
crossref_primary_10_1016_j_impact_2019_100171
crossref_primary_10_3390_nano9030337
crossref_primary_10_1016_j_jddst_2023_104899
crossref_primary_10_3390_bioengineering10080986
crossref_primary_10_1016_j_indcrop_2020_112762
crossref_primary_10_3390_pharmaceutics13081125
crossref_primary_10_1021_acssuschemeng_7b03924
crossref_primary_10_1002_cssc_202000783
crossref_primary_10_1002_smll_201901642
crossref_primary_10_1021_acsnano_3c09924
crossref_primary_10_1016_j_biomaterials_2019_02_025
crossref_primary_10_1016_j_heliyon_2024_e25270
crossref_primary_10_1021_acsomega_9b01392
crossref_primary_10_1039_D4MH01680G
crossref_primary_10_1016_j_chemosphere_2020_126170
crossref_primary_10_1016_j_ijbiomac_2022_09_077
Cites_doi 10.1038/nature02761
10.4049/jimmunol.0802113
10.1016/j.carbpol.2013.04.086
10.1186/1743-8977-6-14
10.1186/1743-8977-10-53
10.1021/cr900339w
10.1016/j.imbio.2004.02.004
10.1039/C5EN00059A
10.1002/(SICI)1099-1263(199603)16:2<129::AID-JAT316>3.0.CO;2-C
10.1002/cjce.20554
10.1016/j.carbpol.2015.11.038
10.1046/j.1365-2249.2002.01768.x
10.1074/jbc.274.16.10689
10.1016/j.cell.2006.02.015
10.1084/jem.20021787
10.2147/IJN.S30596
10.1155/2011/837875
10.1002/jat.2550150110
10.1111/j.1365-2567.2004.01976.x
10.4049/jimmunol.165.10.5780
10.3109/17435391003628713
10.1016/S0092-8674(02)01201-1
10.1016/j.carbpol.2010.12.066
10.1021/am1006222
10.1016/j.ejphar.2011.06.046
10.3233/BME-2012-0697
10.1016/j.eurpolymj.2012.06.013
10.1088/0957-4484/24/7/075103
10.1016/0146-6453(94)90029-9
10.1016/j.jff.2015.08.011
10.1016/j.intimp.2011.02.016
10.1080/08958370290084584
10.1021/bm049300p
10.1016/j.colsurfb.2014.04.018
10.1021/bk-2009-1017.ch004
10.32964/TJ13.5.19
10.2147/NSA.S64386
10.1186/s12989-014-0040-x
10.1165/ajrcmb/6.2.235
10.1002/smll.201001715
10.1177/0885328214531511
10.1016/0273-2300(92)90040-G
10.1021/bm401364z
10.1089/ind.2014.0024
10.1039/C4NR01756K
10.1007/s10570-011-9533-z
10.1002/(SICI)1099-1263(199703)17:2<137::AID-JAT423>3.0.CO;2-I
10.1186/s12989-016-0140-x
10.1007/s10570-011-9630-z
10.1016/j.carbpol.2014.10.007
10.4049/jimmunol.181.6.4279
10.1021/bm200865j
10.1016/j.eurpolymj.2014.07.025
10.1002/(SICI)1099-1263(200001/02)20:1<49::AID-JAT627>3.0.CO;2-L
10.1006/faat.1995.1144
10.1186/1556-276X-7-192
10.1038/ncomms8564
10.1016/j.carbpol.2012.02.066
10.1142/S1793984412410061
10.1016/j.carbpol.2009.10.045
10.1021/sc500153k
10.1016/j.tiv.2005.01.001
10.1021/acs.biomac.5b00055
ContentType Journal Article
Copyright Copyright © 2016 American Chemical Society
Copyright_xml – notice: Copyright © 2016 American Chemical Society
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7S9
L.6
DOI 10.1021/acs.biomac.6b00756
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
AGRICOLA
AGRICOLA - Academic
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
AGRICOLA
AGRICOLA - Academic
DatabaseTitleList MEDLINE
AGRICOLA
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Chemistry
EISSN 1526-4602
EndPage 3473
ExternalDocumentID 27709894
10_1021_acs_biomac_6b00756
a872914826
Genre Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: NIEHS NIH HHS
  grantid: R01 ES019304
GroupedDBID -
02
23N
53G
55A
5GY
7~N
AABXI
ABFLS
ABMVS
ABPTK
ABUCX
ACGFS
ACS
AEESW
AENEX
AFEFF
ALMA_UNASSIGNED_HOLDINGS
AQSVZ
CS3
DU5
EBS
ED
ED~
EJD
F5P
GNL
IH9
JG
JG~
P2P
RNS
ROL
RSW
TN5
UI2
VF5
VG9
W1F
X
XKZ
---
-~X
4.4
5VS
AAHBH
AAYXX
ABBLG
ABJNI
ABLBI
ABQRX
ADHLV
AHGAQ
BAANH
CITATION
CUPRZ
GGK
ZCA
~02
CGR
CUY
CVF
ECM
EIF
NPM
7S9
L.6
ID FETCH-LOGICAL-a375t-b9275c9e7f8432c180b37039e07ded7d7cde04afeb0ff0bda5f1da5cadd2af713
IEDL.DBID ACS
ISSN 1525-7797
1526-4602
IngestDate Fri Jul 11 08:41:23 EDT 2025
Mon Jul 21 05:55:44 EDT 2025
Tue Jul 01 04:07:53 EDT 2025
Thu Apr 24 23:03:52 EDT 2025
Thu Aug 27 13:42:52 EDT 2020
IsPeerReviewed true
IsScholarly true
Issue 11
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-a375t-b9275c9e7f8432c180b37039e07ded7d7cde04afeb0ff0bda5f1da5cadd2af713
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
PMID 27709894
PQID 2000528981
PQPubID 24069
PageCount 10
ParticipantIDs proquest_miscellaneous_2000528981
pubmed_primary_27709894
crossref_primary_10_1021_acs_biomac_6b00756
crossref_citationtrail_10_1021_acs_biomac_6b00756
acs_journals_10_1021_acs_biomac_6b00756
ProviderPackageCode JG~
55A
AABXI
GNL
VF5
XKZ
7~N
VG9
W1F
ACS
AEESW
AFEFF
ABMVS
ABUCX
IH9
AQSVZ
ED~
UI2
CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2016-11-14
PublicationDateYYYYMMDD 2016-11-14
PublicationDate_xml – month: 11
  year: 2016
  text: 2016-11-14
  day: 14
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Biomacromolecules
PublicationTitleAlternate Biomacromolecules
PublicationYear 2016
Publisher American Chemical Society
Publisher_xml – name: American Chemical Society
References ref9/cit9
ref45/cit45
ref3/cit3
ref27/cit27
ref63/cit63
ref56/cit56
ref16/cit16
ref23/cit23
ref8/cit8
ref31/cit31
ref59/cit59
ref2/cit2
(ref50/cit50) 2002
ref34/cit34
ref71/cit71
ref37/cit37
ref20/cit20
ref48/cit48
ref60/cit60
ref74/cit74
ref17/cit17
ref10/cit10
ref35/cit35
ICRP (ref53/cit53) 1994; 24
ref19/cit19
ref21/cit21
ref42/cit42
ref46/cit46
ref49/cit49
ref13/cit13
Warheit D. B. (ref30/cit30) 1998; 1153
ref61/cit61
Nelson K. (ref12/cit12) 2014; 13
ref67/cit67
ref24/cit24
ref38/cit38
ref64/cit64
ref54/cit54
ref6/cit6
ref36/cit36
ref18/cit18
ref65/cit65
ref11/cit11
ref25/cit25
ref29/cit29
ref72/cit72
ref32/cit32
ref39/cit39
ref57/cit57
ref5/cit5
ref51/cit51
ref43/cit43
ref28/cit28
ref40/cit40
ref68/cit68
Bates D. V. (ref52/cit52) 1966; 12
ref26/cit26
ref55/cit55
ref73/cit73
ref69/cit69
ref62/cit62
ref66/cit66
ref41/cit41
ref58/cit58
ref22/cit22
ref33/cit33
ref4/cit4
ref47/cit47
ref1/cit1
ref44/cit44
ref70/cit70
ref7/cit7
References_xml – ident: ref65/cit65
  doi: 10.1038/nature02761
– ident: ref74/cit74
  doi: 10.4049/jimmunol.0802113
– ident: ref43/cit43
  doi: 10.1016/j.carbpol.2013.04.086
– ident: ref59/cit59
  doi: 10.1186/1743-8977-6-14
– ident: ref47/cit47
  doi: 10.1186/1743-8977-10-53
– ident: ref10/cit10
  doi: 10.1021/cr900339w
– ident: ref55/cit55
– ident: ref72/cit72
  doi: 10.1016/j.imbio.2004.02.004
– ident: ref21/cit21
  doi: 10.1039/C5EN00059A
– ident: ref29/cit29
  doi: 10.1002/(SICI)1099-1263(199603)16:2<129::AID-JAT316>3.0.CO;2-C
– ident: ref1/cit1
  doi: 10.1002/cjce.20554
– ident: ref18/cit18
  doi: 10.1016/j.carbpol.2015.11.038
– ident: ref20/cit20
  doi: 10.1046/j.1365-2249.2002.01768.x
– ident: ref66/cit66
  doi: 10.1074/jbc.274.16.10689
– ident: ref11/cit11
– ident: ref71/cit71
  doi: 10.1016/j.cell.2006.02.015
– ident: ref73/cit73
  doi: 10.1084/jem.20021787
– ident: ref41/cit41
  doi: 10.2147/IJN.S30596
– ident: ref3/cit3
  doi: 10.1155/2011/837875
– ident: ref28/cit28
  doi: 10.1002/jat.2550150110
– ident: ref67/cit67
  doi: 10.1111/j.1365-2567.2004.01976.x
– ident: ref68/cit68
  doi: 10.4049/jimmunol.165.10.5780
– ident: ref8/cit8
– ident: ref26/cit26
  doi: 10.3109/17435391003628713
– ident: ref70/cit70
  doi: 10.1016/S0092-8674(02)01201-1
– volume: 12
  start-page: 173
  issue: 2
  year: 1966
  ident: ref52/cit52
  publication-title: Health Phys.
– ident: ref4/cit4
  doi: 10.1016/j.carbpol.2010.12.066
– ident: ref56/cit56
  doi: 10.1021/am1006222
– ident: ref60/cit60
  doi: 10.1016/j.ejphar.2011.06.046
– ident: ref31/cit31
  doi: 10.3233/BME-2012-0697
– ident: ref19/cit19
  doi: 10.1016/j.eurpolymj.2012.06.013
– ident: ref36/cit36
  doi: 10.1088/0957-4484/24/7/075103
– volume: 24
  start-page: 1
  year: 1994
  ident: ref53/cit53
  publication-title: Ann. ICRP
  doi: 10.1016/0146-6453(94)90029-9
– ident: ref64/cit64
  doi: 10.1016/j.jff.2015.08.011
– ident: ref57/cit57
  doi: 10.1016/j.intimp.2011.02.016
– ident: ref25/cit25
  doi: 10.1080/08958370290084584
– ident: ref45/cit45
  doi: 10.1021/bm049300p
– ident: ref63/cit63
  doi: 10.1016/j.colsurfb.2014.04.018
– ident: ref27/cit27
  doi: 10.1021/bk-2009-1017.ch004
– ident: ref38/cit38
– ident: ref48/cit48
– volume: 13
  start-page: 19
  issue: 5
  year: 2014
  ident: ref12/cit12
  publication-title: TAPPI Journal
  doi: 10.32964/TJ13.5.19
– ident: ref62/cit62
  doi: 10.2147/NSA.S64386
– ident: ref33/cit33
  doi: 10.1186/s12989-014-0040-x
– ident: ref54/cit54
  doi: 10.1165/ajrcmb/6.2.235
– ident: ref16/cit16
  doi: 10.1002/smll.201001715
– ident: ref42/cit42
  doi: 10.1177/0885328214531511
– ident: ref49/cit49
  doi: 10.1016/0273-2300(92)90040-G
– ident: ref13/cit13
– ident: ref34/cit34
  doi: 10.1021/bm401364z
– ident: ref22/cit22
  doi: 10.1089/ind.2014.0024
– ident: ref9/cit9
  doi: 10.1039/C4NR01756K
– ident: ref6/cit6
  doi: 10.1007/s10570-011-9533-z
– ident: ref24/cit24
  doi: 10.1002/(SICI)1099-1263(199703)17:2<137::AID-JAT423>3.0.CO;2-I
– ident: ref40/cit40
  doi: 10.1186/s12989-016-0140-x
– ident: ref44/cit44
  doi: 10.1007/s10570-011-9630-z
– ident: ref7/cit7
  doi: 10.1016/j.carbpol.2014.10.007
– ident: ref69/cit69
  doi: 10.4049/jimmunol.181.6.4279
– ident: ref37/cit37
  doi: 10.1021/bm200865j
– ident: ref23/cit23
  doi: 10.1016/j.eurpolymj.2014.07.025
– volume: 1153
  start-page: 579
  year: 1998
  ident: ref30/cit30
  publication-title: Int. Congr Ser.
– ident: ref35/cit35
  doi: 10.1002/(SICI)1099-1263(200001/02)20:1<49::AID-JAT627>3.0.CO;2-L
– ident: ref51/cit51
  doi: 10.1006/faat.1995.1144
– ident: ref2/cit2
  doi: 10.1186/1556-276X-7-192
– ident: ref46/cit46
  doi: 10.1038/ncomms8564
– ident: ref17/cit17
  doi: 10.1016/j.carbpol.2012.02.066
– ident: ref32/cit32
  doi: 10.1142/S1793984412410061
– ident: ref5/cit5
  doi: 10.1016/j.carbpol.2009.10.045
– ident: ref39/cit39
  doi: 10.1021/sc500153k
– ident: ref61/cit61
  doi: 10.1016/j.tiv.2005.01.001
– volume-title: Multiple Path Particle Dosimetry Model (MPPD v 1.0): A Model for Human and Rat Airway Particle Dosimetry
  year: 2002
  ident: ref50/cit50
– ident: ref58/cit58
  doi: 10.1021/acs.biomac.5b00055
SSID ssj0009345
Score 2.365436
Snippet A significant amount of research toward commercial development of cellulose based nanomaterials (CNM) is now in progress with some potential applications....
SourceID proquest
pubmed
crossref
acs
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 3464
SubjectTerms A549 Cells
cellulose
Cellulose - adverse effects
Cellulose - chemistry
Cellulose - pharmacology
cytotoxicity
Humans
inflammation
Lignin - adverse effects
Lignin - chemistry
Lignin - pharmacology
nanomaterials
Nanostructures - adverse effects
Nanostructures - chemistry
Title In Vitro Toxicity Evaluation of Lignin-(Un)coated Cellulose Based Nanomaterials on Human A549 and THP‑1 Cells
URI http://dx.doi.org/10.1021/acs.biomac.6b00756
https://www.ncbi.nlm.nih.gov/pubmed/27709894
https://www.proquest.com/docview/2000528981
Volume 17
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Li9RAEC7W9aAX34_xRQuCima2O69OjuOwyyiuCM7I3kI_qmXYoSObDIgn_4J_cX_JVieZEdFd9hJCSHXo7krVV1TXVwAvAsGLIiMYYWrzKNxGiiukKEVlwiSoDQ_FyYef8tki_XCUHe3A23My-LHYU6YZh1J0Gj7XwcPlV-BqnBcyhFqT6Zc_FLtJ15I4NPQhzFjKoUTm_2MEZ2Sav53ROQiz8zQHN-FwU6_THzA5Hq9bPTY__6VvvNQkbsGNAXKySa8jt2EH_R24Nt10ersL9XvPvi7bk5rN6x9LQ7ic7W9JwFnt2MflN7_00auFf21qAqeWTXG1Wq_qBtk7coOWkZGmz7a9OjOS6pIDbEJxIVPesvns8-mv36KTa-7B4mB_Pp1FQyOGSCUyayNdxjIzJUpXpElsRMF1QpaiRC4tWmmlschT5VBz57i2KnOCLoZsZ6wchcH3YdfXHh8Cc5mQBS9VqQ3FZoVUPEbrpMacI9doR_CS1qoafqSm6nLksajCw34Bq2EBRyA2e1eZgc88tNVYXSjzZivzvWfzuPDt5xuVqGhHQiZFeazXTejdyTMKVQsxgge9rmzHi6XkgdX-0aVn8hiuEwzLQ4WjSJ_AbnuyxqcEdVr9rNPwMzmy-wQ
linkProvider American Chemical Society
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1La9wwEBZpckgvbZM-sn2qUGhLcSr5Jfu4XRI26SYU6i25GT1GYekil9gLpaf-hf7F_JKMbO-GljQkF2OER9ZjrPmG8XxDyBtP8CLxEAwgNmngbwPJJKCXIhOuI1Ca-eTko-N0PI0PT5KTPo_b58LgIGrsqW6D-JfsAvyjb_MZ6fiWVHlDl94hG4hGQu9xDUdfL5l2o7Yysa_rg9AxF32mzNV9eJuk679t0n-AZmtw9u-TYjXU9j-T77uLRu3qX_-wON5yLg_IvR6A0mGnMVtkDdw22Rwt6749JNWBo99mzVlFi-rnTCNKp3srSnBaWTqZnbqZC95N3XtdIVQ1dATz-WJe1UA_oVE0FI9sfG3TKTdFqTZUQIfoJVLpDC3GX85__-GtXP2ITPf3itE46MsyBDISSROoPBSJzkHYLI5CzTOmIjw3cmDCgBFGaAMslhYUs5YpIxPL8aLxJA2lRaf4MVl3lYMdQm3CRcZymSuNnlomJAvBWKEgZcAUmAF5i2tV9p9VXbYR85CXvrFbwLJfwAHhyy0sdc9u7otszK-V-bCS-dFxe1z79OulZpS4Iz6uIh1Ui9pX8mQJOq4ZH5Anncqs-guFYJ7j_umNZ_KKbI6Lo0k5OTj-_IzcRYCW-txHHj8n683ZAl4gCGrUy1bpLwCI_QN0
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Zi9RAEG50BfXFe3U8WxBUlux25-rkcRx3mNV1WXBG5i30US2DQ7JsMiA--Rf2L-4vsSrJjCi6iC8hhFSf1XWkUl8x9oIAXjQKwQBilwZ0G2ihAb0UnUgbgbGCkpM_HKWTWfxunsz7TxeUC4ODqLGlug3i06k-cb5HGJB79Jyy0rGn1JCySy-zKxS3I69rOPr4E203aqsTU20fNB9z1WfL_LkN0ku2_lUv_cXYbJXO-Cabb4bb_mvyZXfVmF377Tckx_-Yzy12ozdE-bDjnNvsEpR32LXRuv7bXVYdlPzTojmt-LT6urBorfP9DTQ4rzw_XHwuF2Xwala-thWarI6PYLlcLasa-BtUjo6j6MZum47JOVK1IQM-RG-R69Lx6eT4_PuZbOnqe2w23p-OJkFfniHQkUqawOShSmwOymdxFFqZCROh_MhBKAdOOWUdiFh7MMJ7YZxOvMSLRYkaao_O8TbbKqsSHjDuE6kykevcWPTYMqVFCM4rA6kAYcAN2Etcq6I_XnXRRs5DWdDDbgGLfgEHTK63sbA9yjkV21heSLOzoTnpMD4ufPv5mjsK3BGKr-gSqlVNFT1Fgg5sJgfsfsc2m_ZCpQRh3T_855k8Y1eP346Lw4Oj94_YdbTTUkqBlPFjttWcruAJ2kKNedry_Q_gvgX3
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=In+Vitro+Toxicity+Evaluation+of+Lignin-%28Un%29coated+Cellulose+Based+Nanomaterials+on+Human+A549+and+THP%E2%80%911+Cells&rft.jtitle=Biomacromolecules&rft.au=Yanamala%2C+Naveena&rft.au=Kisin%2C+Elena+R&rft.au=Menas%2C+Autumn+L&rft.au=Farcas%2C+Mariana+T&rft.date=2016-11-14&rft.pub=American+Chemical+Society&rft.issn=1525-7797&rft.eissn=1526-4602&rft.volume=17&rft.issue=11&rft.spage=3464&rft.epage=3473&rft_id=info:doi/10.1021%2Facs.biomac.6b00756&rft.externalDocID=a872914826
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1525-7797&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1525-7797&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1525-7797&client=summon