The Amino-Acid Substituents of Dipeptide Substrates of Cathepsin C Can Determine the Rate-Limiting Steps of Catalysis - Rubach, Jon K; Cui, Guanglei; Schneck, Jessica L; Taylor, Amy N; Zhao, Baoguang; Smallwood, Angela; Nevins, Neysa; Wisnoski, David; Thrall, Sara H; Meek, Thomas D (Biochemistry (Easton), 2012)
Keywords: acylation; amino acids; Amino Acids - chemistry; Catalysis; catalytic activity; Cathepsin C - chemistry; Cathepsin C - genetics; cysteine proteinases; Dipeptides - chemistry; dipeptidyl-peptidase I; drugs; Humans; Hydrogen-Ion Concentration; hydrolysis; isotopes; Kinetics; molecular dynamics; Molecular Dynamics Simulation; solvents; Substrate Specificity