Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP)

• Published in: Biochemistry (Easton) Vol. 42; no. 27; pp. 8223 - 8231
• Main Authors: Franklin, Matthew C, Kadkhodayan, Saloumeh, Ackerly, Heidi, Alexandru, Daniela, Distefano, Mark D, Elliott, Linda O, Flygare, John A, Mausisa, Grace, Okawa, David C, Ong, Danny, Vucic, Domagoj, Deshayes, Kurt, Fairbrother, Wayne J
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 15.07.2003
• Subjects: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Carrier Proteins - chemistry; Carrier Proteins - genetics; Carrier Proteins - physiology; Crystallography, X-Ray; Genetic Linkage; Inhibitor of Apoptosis Proteins; Models, Molecular; Molecular Sequence Data; Neoplasm Proteins - chemistry; Neoplasm Proteins - genetics; Neoplasm Proteins - physiology; Sequence Homology, Amino Acid; Structure-Activity Relationship; X Chromosome

Melanoma inhibitor of apoptosis (ML-IAP) is a potent anti-apoptotic protein that is upregulated in a number of melanoma cell lines but not expressed in most normal adult tissues. Overexpression of IAP proteins, such as ML-IAP or the ubiquitously expressed X-chromosome-linked IAP (XIAP), in human can...