Translatable High Drug Loading Drug Delivery Systems Based on Biocompatible Polymer Nanocarriers

• Published in: Biomacromolecules Vol. 19; no. 6; pp. 1732 - 1745
• Main Authors: Chen, Weizhi, Zhou, Sensen, Ge, Lei, Wu, Wei, Jiang, Xiqun
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 11.06.2018
• Subjects: adverse effects; albumins; Albumins - chemistry; Biocompatible Materials - chemistry; casein; Caseins - chemistry; Drug Carriers - chemistry; Drug Carriers - pharmacokinetics; Drug Delivery Systems - methods; drugs; genes; Humans; nanocarriers; Nanostructures - administration & dosage; Nanostructures - chemistry; nucleic acids; Nucleic Acids - chemistry; Oxazoles - chemistry; Peptides - chemistry; polyethylene glycol; Polyethylene Glycols - chemistry; Polymers - chemistry; polypeptides; Polyvinyls - chemistry; Pyrrolidines - chemistry

Most nanocarriers possess low drug loading, resulting in frequently repeated administration and thereby high cost and increased side effects. Furthermore, the characteristics of nanocarrier materials, especially the drug loading capacity, plays a vital role in the drug delivery efficacy. In this rev...