Translatable High Drug Loading Drug Delivery Systems Based on Biocompatible Polymer Nanocarriers

• Published in: Biomacromolecules Vol. 19; no. 6; pp. 1732 - 1745
• Main Authors: Chen, Weizhi, Zhou, Sensen, Ge, Lei, Wu, Wei, Jiang, Xiqun
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 11.06.2018
• Subjects: adverse effects; albumins; Albumins - chemistry; Biocompatible Materials - chemistry; casein; Caseins - chemistry; Drug Carriers - chemistry; Drug Carriers - pharmacokinetics; Drug Delivery Systems - methods; drugs; genes; Humans; nanocarriers; Nanostructures - administration & dosage; Nanostructures - chemistry; nucleic acids; Nucleic Acids - chemistry; Oxazoles - chemistry; Peptides - chemistry; polyethylene glycol; Polyethylene Glycols - chemistry; Polymers - chemistry; polypeptides; Polyvinyls - chemistry; Pyrrolidines - chemistry
• ISSN: 1525-7797; 1526-4602; 1526-4602
• DOI: 10.1021/acs.biomac.8b00218

Most nanocarriers possess low drug loading, resulting in frequently repeated administration and thereby high cost and increased side effects. Furthermore, the characteristics of nanocarrier materials, especially the drug loading capacity, plays a vital role in the drug delivery efficacy. In this review, we focus on the readily translatable polymeric drug delivery systems with high drug loading, which are comprised of biocompatible polymers such as poly­(ethylene glycol), poly­(N-vinylpyrrolidone), polyoxazoline, natural proteins like albumin and casein, non-natural proteins such as recombinant elastin-like polypeptides, as well as nucleic acids. At the end of this review, applications of these polymeric nanocarriers on the delivery of proteins and gene drugs are also briefly discussed.