Biological Activities and Emerging Roles of Lignin and Lignin-Based ProductsA Review
Bioactive substances, displaying excellent biocompatibility, chemical stability, and processability, could be extensively applied in biomedicine and tissue engineering. In recent years, plant-based bioactive substances such as flavonoids, vitamins, terpenes, and lignin have received considerable att...
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| Published in | Biomacromolecules Vol. 22; no. 12; pp. 4905 - 4918 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Chemical Society
13.12.2021
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Bioactive substances, displaying excellent biocompatibility, chemical stability, and processability, could be extensively applied in biomedicine and tissue engineering. In recent years, plant-based bioactive substances such as flavonoids, vitamins, terpenes, and lignin have received considerable attention due to their human health benefits and pharmaceutical/medical applications. Among them is lignin, an amorphous biomacromolecule mainly derived from the combinatorial radical coupling of three phenylpropane units (p-hydroxypenyl, guaiacyl, and syringyl) during lignification. Lignin possesses intrinsic bioactivities (antioxidative, antibacterial, anti-UV activities, etc.) against phytopathogens. Lignin also enhances the plant resistance (adaptability) against environmental stresses. The abundant structural features of lignin offer other significant bioactivities including antitumor and antivirus bioactivities, regulation of plant growth, and enzymatic hydrolysis of cellulose. This Review reports the latest research results on the bioactive potential of lignin and lignin-based substances in biomedicine, agriculture, and biomass conversion. Moreover, the interfacial reactions and bonding mechanisms of lignin with biotissue/cells and other constituents were also discussed, aiming at promoting the conversion or evolution of lignin from industrial wastes to value-added bioactive materials. |
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| AbstractList | Bioactive substances, displaying excellent biocompatibility, chemical stability, and processability, could be extensively applied in biomedicine and tissue engineering. In recent years, plant-based bioactive substances such as flavonoids, vitamins, terpenes, and lignin have received considerable attention due to their human health benefits and pharmaceutical/medical applications. Among them is lignin, an amorphous biomacromolecule mainly derived from the combinatorial radical coupling of three phenylpropane units (p-hydroxypenyl, guaiacyl, and syringyl) during lignification. Lignin possesses intrinsic bioactivities (antioxidative, antibacterial, anti-UV activities, etc.) against phytopathogens. Lignin also enhances the plant resistance (adaptability) against environmental stresses. The abundant structural features of lignin offer other significant bioactivities including antitumor and antivirus bioactivities, regulation of plant growth, and enzymatic hydrolysis of cellulose. This Review reports the latest research results on the bioactive potential of lignin and lignin-based substances in biomedicine, agriculture, and biomass conversion. Moreover, the interfacial reactions and bonding mechanisms of lignin with biotissue/cells and other constituents were also discussed, aiming at promoting the conversion or evolution of lignin from industrial wastes to value-added bioactive materials. Bioactive substances, displaying excellent biocompatibility, chemical stability, and processability, could be extensively applied in biomedicine and tissue engineering. In recent years, plant-based bioactive substances such as flavonoids, vitamins, terpenes, and lignin have received considerable attention due to their human health benefits and pharmaceutical/medical applications. Among them is lignin, an amorphous biomacromolecule mainly derived from the combinatorial radical coupling of three phenylpropane units ( -hydroxypenyl, guaiacyl, and syringyl) during lignification. Lignin possesses intrinsic bioactivities (antioxidative, antibacterial, anti-UV activities, etc.) against phytopathogens. Lignin also enhances the plant resistance (adaptability) against environmental stresses. The abundant structural features of lignin offer other significant bioactivities including antitumor and antivirus bioactivities, regulation of plant growth, and enzymatic hydrolysis of cellulose. This Review reports the latest research results on the bioactive potential of lignin and lignin-based substances in biomedicine, agriculture, and biomass conversion. Moreover, the interfacial reactions and bonding mechanisms of lignin with biotissue/cells and other constituents were also discussed, aiming at promoting the conversion or evolution of lignin from industrial wastes to value-added bioactive materials. Bioactive substances, displaying excellent biocompatibility, chemical stability, and processability, could be extensively applied in biomedicine and tissue engineering. In recent years, plant-based bioactive substances such as flavonoids, vitamins, terpenes, and lignin have received considerable attention due to their human health benefits and pharmaceutical/medical applications. Among them is lignin, an amorphous biomacromolecule mainly derived from the combinatorial radical coupling of three phenylpropane units (p-hydroxypenyl, guaiacyl, and syringyl) during lignification. Lignin possesses intrinsic bioactivities (antioxidative, antibacterial, anti-UV activities, etc.) against phytopathogens. Lignin also enhances the plant resistance (adaptability) against environmental stresses. The abundant structural features of lignin offer other significant bioactivities including antitumor and antivirus bioactivities, regulation of plant growth, and enzymatic hydrolysis of cellulose. This Review reports the latest research results on the bioactive potential of lignin and lignin-based substances in biomedicine, agriculture, and biomass conversion. Moreover, the interfacial reactions and bonding mechanisms of lignin with biotissue/cells and other constituents were also discussed, aiming at promoting the conversion or evolution of lignin from industrial wastes to value-added bioactive materials.Bioactive substances, displaying excellent biocompatibility, chemical stability, and processability, could be extensively applied in biomedicine and tissue engineering. In recent years, plant-based bioactive substances such as flavonoids, vitamins, terpenes, and lignin have received considerable attention due to their human health benefits and pharmaceutical/medical applications. Among them is lignin, an amorphous biomacromolecule mainly derived from the combinatorial radical coupling of three phenylpropane units (p-hydroxypenyl, guaiacyl, and syringyl) during lignification. Lignin possesses intrinsic bioactivities (antioxidative, antibacterial, anti-UV activities, etc.) against phytopathogens. Lignin also enhances the plant resistance (adaptability) against environmental stresses. The abundant structural features of lignin offer other significant bioactivities including antitumor and antivirus bioactivities, regulation of plant growth, and enzymatic hydrolysis of cellulose. This Review reports the latest research results on the bioactive potential of lignin and lignin-based substances in biomedicine, agriculture, and biomass conversion. Moreover, the interfacial reactions and bonding mechanisms of lignin with biotissue/cells and other constituents were also discussed, aiming at promoting the conversion or evolution of lignin from industrial wastes to value-added bioactive materials. |
| Author | Shu, Fan Jiang, Bo Li, Mohan Yuan, Yufeng Wu, Wenjuan Jin, Yongcan Xiao, Huining |
| AuthorAffiliation | Department of Chemical Engineering Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Jiangsu Provincial Key Lab of Pulp and Paper Science and Technology Joint International Research Lab of Lignocellulosic Functional Materials, International Innovation Center for Forest Chemicals and Materials |
| AuthorAffiliation_xml | – name: Department of Chemical Engineering – name: Joint International Research Lab of Lignocellulosic Functional Materials, International Innovation Center for Forest Chemicals and Materials – name: Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Jiangsu Provincial Key Lab of Pulp and Paper Science and Technology |
| Author_xml | – sequence: 1 givenname: Fan surname: Shu fullname: Shu, Fan organization: Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Jiangsu Provincial Key Lab of Pulp and Paper Science and Technology – sequence: 2 givenname: Bo surname: Jiang fullname: Jiang, Bo organization: Joint International Research Lab of Lignocellulosic Functional Materials, International Innovation Center for Forest Chemicals and Materials – sequence: 3 givenname: Yufeng surname: Yuan fullname: Yuan, Yufeng organization: Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Jiangsu Provincial Key Lab of Pulp and Paper Science and Technology – sequence: 4 givenname: Mohan surname: Li fullname: Li, Mohan organization: Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Jiangsu Provincial Key Lab of Pulp and Paper Science and Technology – sequence: 5 givenname: Wenjuan surname: Wu fullname: Wu, Wenjuan email: wenjuanwu@njfu.edu.cn organization: Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Jiangsu Provincial Key Lab of Pulp and Paper Science and Technology – sequence: 6 givenname: Yongcan orcidid: 0000-0002-0748-3629 surname: Jin fullname: Jin, Yongcan email: jinyongcan@njfu.edu.cn organization: Joint International Research Lab of Lignocellulosic Functional Materials, International Innovation Center for Forest Chemicals and Materials – sequence: 7 givenname: Huining orcidid: 0000-0003-3500-2308 surname: Xiao fullname: Xiao, Huining organization: Department of Chemical Engineering |
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| Cites_doi | 10.1016/j.copbio.2019.02.018 10.1080/01635589809514637 10.1074/jbc.M704257200 10.4236/as.2017.85025 10.1126/science.1193748 10.1002/jctb.5656 10.3177/jnsv.61.449 10.1111/j.1742-7843.2010.00575.x 10.1111/jipb.12422 10.1038/nature13084 10.1016/j.carbpol.2020.117429 10.1039/C6RA01866A 10.1016/j.biortech.2021.126142 10.1007/s12155-012-9273-4 10.1104/pp.114.245597 10.13360/j.issn.2096-1359.201909026 10.1111/1751-7915.13392 10.1007/s10584-006-9210-7 10.1021/acssuschemeng.8b03262 10.3390/nano11040846 10.1111/j.1365-3040.2005.01432.x 10.1016/j.ijbiomac.2014.09.044 10.1094/MPMI-10-14-0320-R 10.1080/02773813.2013.851246 10.1016/j.msec.2019.110002 10.1371/journal.pone.0131219 10.1021/acsabm.8b00445 10.1016/j.biortech.2012.10.065 10.1016/j.fsi.2017.11.037 10.1007/s11104-014-2131-8 10.2147/COPD.S10770 10.1016/j.copbio.2013.09.008 10.1016/j.bbrc.2015.04.104 10.1016/j.pupt.2012.12.009 10.1021/jf502062b 10.1111/j.1469-8137.2004.01143.x 10.3390/molecules201119671 10.1016/j.pecs.2019.100788 10.1016/j.actbio.2021.01.016 10.1016/S2095-3119(18)61905-7 10.1016/j.phytochem.2007.03.022 10.1021/acssuschemeng.0c02880 10.1007/s12298-015-0289-z 10.1177/088532828700200406 10.1016/j.biortech.2020.124441 10.1021/sc500087z 10.1016/j.biortech.2015.01.026 10.1016/j.bmc.2007.11.041 10.1016/j.ijbiomac.2016.11.100 10.1186/1754-6834-6-156 10.1039/C5GC03043A 10.1016/j.pharmthera.2010.05.004 10.3390/ijms18030619 10.1016/j.biortech.2019.122133 10.1007/s00344-017-9696-4 10.1016/j.bmc.2006.07.066 10.1007/s11104-015-2780-2 10.1039/C6NP00112B 10.18632/oncotarget.24990 10.1007/s13346-017-0441-0 10.1038/nnano.2015.141 10.1016/j.indcrop.2011.06.002 10.1007/s12649-020-01088-0 10.1016/j.thromres.2014.08.024 10.1186/1471-2229-13-44 10.1016/S0960-8524(97)00181-8 10.1016/j.ijbiomac.2018.06.067 10.1016/j.plantsci.2014.10.005 10.1021/acsomega.8b00697 10.1016/j.renene.2018.02.079 10.1016/j.procbio.2018.05.007 10.1186/1753-6561-5-S7-P103 10.3144/expresspolymlett.2009.46 10.1016/j.ijbiomac.2014.12.044 10.1097/SS.0b013e3181bf1e03 10.1021/acs.biomac.0c00695 10.1016/j.biortech.2005.11.014 10.1016/j.jobab.2020.04.001 10.1016/j.biomaterials.2016.12.034 10.1016/j.indcrop.2007.07.019 10.1016/j.msec.2019.04.038 10.11648/j.ijnfs.20140303.16 10.1111/j.1744-7909.2010.00892.x 10.1016/S1001-0742(08)62296-2 10.1016/j.biotechadv.2019.107416 10.3389/fpls.2020.00581 10.1016/j.indcrop.2016.07.023 10.1007/s11104-014-2290-7 10.1016/j.ijbiomac.2019.12.085 10.3390/catal7120374 10.1007/s11103-019-00849-3 10.1063/1.4824019 10.1016/j.jddst.2017.09.017 10.1016/j.indcrop.2016.09.046 10.1080/19476337.2012.688219 10.1016/j.biortech.2004.02.024 10.1016/j.ijbiomac.2020.03.016 10.1002/app.42069 10.1039/C8GC04059A 10.1016/j.copbio.2018.11.012 10.1007/s12033-012-9538-3 10.1039/C4GC01333F 10.1016/j.ijbiomac.2015.01.012 10.1016/j.pmatsci.2017.12.001 10.1007/s13399-019-00458-6 10.1007/s00425-006-0300-6 10.15376/biores.2.3.363-370 10.1271/bbb.100645 10.1007/s10570-014-0237-z 10.1016/j.ijbiomac.2018.08.109 10.1016/j.rser.2015.04.091 10.1371/journal.pone.0035906 10.1002/app.28097 10.1016/j.ijbiomac.2016.01.109 10.3390/cosmetics7040085 10.1016/j.actbio.2021.05.032 10.1016/j.ijantimicag.2016.08.014 10.1016/j.antiviral.2007.03.010 10.1126/science.1227491 10.1160/TH09-07-0454 10.1016/j.cbpa.2015.06.009 10.1021/acssuschemeng.8b02011 10.3389/fpls.2013.00273 10.1016/j.jobab.2020.07.002 10.1016/j.foodchem.2010.10.113 10.1111/j.1365-313X.2009.03996.x 10.1111/jth.13254 10.3390/ijms14046960 10.1016/j.jobab.2021.01.002 10.1016/j.bioactmat.2020.04.007 10.1039/C5GC01054C 10.1186/s13068-020-1659-5 10.1016/j.msec.2017.07.054 10.1111/1541-4337.12322 10.1002/bbb.1670 10.1016/0166-3542(91)90039-T 10.1016/j.mehy.2018.09.003 10.1016/j.jbiotec.2003.09.011 |
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| References | ref45/cit45 ref3/cit3 ref81/cit81 Lopez B. S. G. (ref58/cit58) 2009; 23 ref16/cit16 ref52/cit52 Loomis T. (ref71/cit71) 1953; 109 ref114/cit114 ref23/cit23 ref115/cit115 ref116/cit116 ref110/cit110 ref111/cit111 ref2/cit2 ref112/cit112 ref77/cit77 ref113/cit113 ref117/cit117 ref20/cit20 ref48/cit48 ref118/cit118 ref74/cit74 ref119/cit119 ref10/cit10 ref35/cit35 ref89/cit89 ref19/cit19 ref93/cit93 ref42/cit42 ref96/cit96 ref120/cit120 ref13/cit13 ref122/cit122 ref105/cit105 ref67/cit67 ref38/cit38 ref128/cit128 ref90/cit90 ref124/cit124 ref64/cit64 ref126/cit126 ref54/cit54 ref6/cit6 ref18/cit18 ref136/cit136 ref137/cit137 ref65/cit65 ref97/cit97 ref101/cit101 ref11/cit11 ref102/cit102 ref29/cit29 ref76/cit76 ref86/cit86 ref32/cit32 ref39/cit39 Balas A. (ref99/cit99) 2007; 2 ref5/cit5 ref43/cit43 ref80/cit80 ref133/cit133 ref28/cit28 ref132/cit132 ref91/cit91 ref55/cit55 ref12/cit12 ref66/cit66 ref22/cit22 ref121/cit121 ref33/cit33 ref87/cit87 ref106/cit106 ref140/cit140 ref129/cit129 ref44/cit44 ref70/cit70 ref98/cit98 ref125/cit125 ref9/cit9 ref27/cit27 Wang H. J. (ref109/cit109) 2005; 17 ref63/cit63 ref56/cit56 ref92/cit92 ref8/cit8 ref31/cit31 ref59/cit59 ref85/cit85 ref34/cit34 ref37/cit37 ref60/cit60 ref88/cit88 ref17/cit17 ref82/cit82 ref143/cit143 ref53/cit53 ref21/cit21 ref46/cit46 ref49/cit49 Sakagami H. (ref61/cit61) 2011; 25 ref75/cit75 ref24/cit24 ref141/cit141 ref50/cit50 ref78/cit78 ref36/cit36 ref83/cit83 ref138/cit138 ref79/cit79 ref139/cit139 ref100/cit100 ref25/cit25 ref103/cit103 ref72/cit72 ref14/cit14 ref57/cit57 ref51/cit51 ref134/cit134 ref135/cit135 ref40/cit40 ref68/cit68 ref94/cit94 ref130/cit130 ref131/cit131 ref26/cit26 ref142/cit142 ref73/cit73 ref69/cit69 ref15/cit15 ref62/cit62 ref41/cit41 ref95/cit95 ref108/cit108 Li J. F. (ref107/cit107) 2002; 01 ref104/cit104 ref4/cit4 ref30/cit30 ref47/cit47 ref84/cit84 ref127/cit127 ref1/cit1 ref123/cit123 ref7/cit7 |
| References_xml | – ident: ref16/cit16 doi: 10.1016/j.copbio.2019.02.018 – ident: ref62/cit62 doi: 10.1080/01635589809514637 – ident: ref73/cit73 doi: 10.1074/jbc.M704257200 – ident: ref106/cit106 doi: 10.4236/as.2017.85025 – ident: ref54/cit54 doi: 10.1126/science.1193748 – ident: ref36/cit36 doi: 10.1002/jctb.5656 – ident: ref81/cit81 doi: 10.3177/jnsv.61.449 – ident: ref86/cit86 doi: 10.1111/j.1742-7843.2010.00575.x – ident: ref88/cit88 doi: 10.1111/jipb.12422 – ident: ref87/cit87 doi: 10.1038/nature13084 – ident: ref108/cit108 doi: 10.1016/j.carbpol.2020.117429 – ident: ref63/cit63 doi: 10.1039/C6RA01866A – ident: ref135/cit135 doi: 10.1016/j.biortech.2021.126142 – ident: ref131/cit131 doi: 10.1007/s12155-012-9273-4 – ident: ref18/cit18 doi: 10.1104/pp.114.245597 – volume: 23 start-page: 1011 issue: 6 year: 2009 ident: ref58/cit58 publication-title: In Vivo – ident: ref125/cit125 doi: 10.13360/j.issn.2096-1359.201909026 – ident: ref44/cit44 doi: 10.1111/1751-7915.13392 – ident: ref112/cit112 doi: 10.1007/s10584-006-9210-7 – ident: ref67/cit67 doi: 10.1021/acssuschemeng.8b03262 – ident: ref104/cit104 doi: 10.3390/nano11040846 – ident: ref114/cit114 doi: 10.1111/j.1365-3040.2005.01432.x – ident: ref22/cit22 doi: 10.1016/j.ijbiomac.2014.09.044 – ident: ref123/cit123 doi: 10.1094/MPMI-10-14-0320-R – ident: ref139/cit139 doi: 10.1080/02773813.2013.851246 – volume: 17 start-page: 650 issue: 4 year: 2005 ident: ref109/cit109 publication-title: J. Environ. Sci. – ident: ref48/cit48 doi: 10.1016/j.msec.2019.110002 – ident: ref55/cit55 doi: 10.1371/journal.pone.0131219 – ident: ref28/cit28 doi: 10.1021/acsabm.8b00445 – ident: ref138/cit138 doi: 10.1016/j.biortech.2012.10.065 – ident: ref56/cit56 doi: 10.1016/j.fsi.2017.11.037 – ident: ref95/cit95 doi: 10.1007/s11104-014-2131-8 – ident: ref76/cit76 doi: 10.2147/COPD.S10770 – ident: ref128/cit128 doi: 10.1016/j.copbio.2013.09.008 – ident: ref57/cit57 doi: 10.1016/j.bbrc.2015.04.104 – ident: ref77/cit77 doi: 10.1016/j.pupt.2012.12.009 – ident: ref85/cit85 doi: 10.1021/jf502062b – ident: ref91/cit91 doi: 10.1111/j.1469-8137.2004.01143.x – ident: ref100/cit100 doi: 10.3390/molecules201119671 – ident: ref10/cit10 doi: 10.1016/j.pecs.2019.100788 – ident: ref6/cit6 doi: 10.1016/j.actbio.2021.01.016 – ident: ref119/cit119 doi: 10.1016/S2095-3119(18)61905-7 – ident: ref24/cit24 doi: 10.1016/j.phytochem.2007.03.022 – ident: ref17/cit17 doi: 10.1021/acssuschemeng.0c02880 – ident: ref118/cit118 doi: 10.1007/s12298-015-0289-z – ident: ref5/cit5 doi: 10.1177/088532828700200406 – ident: ref98/cit98 doi: 10.1016/j.biortech.2020.124441 – ident: ref20/cit20 doi: 10.1021/sc500087z – ident: ref137/cit137 doi: 10.1016/j.biortech.2015.01.026 – ident: ref52/cit52 doi: 10.1016/j.bmc.2007.11.041 – ident: ref82/cit82 doi: 10.1016/j.ijbiomac.2016.11.100 – ident: ref132/cit132 doi: 10.1186/1754-6834-6-156 – ident: ref11/cit11 doi: 10.1039/C5GC03043A – ident: ref23/cit23 doi: 10.1016/j.pharmthera.2010.05.004 – ident: ref121/cit121 doi: 10.3390/ijms18030619 – ident: ref143/cit143 doi: 10.1016/j.biortech.2019.122133 – ident: ref101/cit101 doi: 10.1007/s00344-017-9696-4 – ident: ref72/cit72 doi: 10.1016/j.bmc.2006.07.066 – ident: ref94/cit94 doi: 10.1007/s11104-015-2780-2 – ident: ref14/cit14 doi: 10.1039/C6NP00112B – ident: ref68/cit68 doi: 10.18632/oncotarget.24990 – ident: ref42/cit42 doi: 10.1007/s13346-017-0441-0 – ident: ref39/cit39 doi: 10.1038/nnano.2015.141 – ident: ref26/cit26 doi: 10.1016/j.indcrop.2011.06.002 – ident: ref70/cit70 doi: 10.1007/s12649-020-01088-0 – ident: ref74/cit74 doi: 10.1016/j.thromres.2014.08.024 – ident: ref115/cit115 doi: 10.1186/1471-2229-13-44 – ident: ref126/cit126 doi: 10.1016/S0960-8524(97)00181-8 – ident: ref50/cit50 doi: 10.1016/j.ijbiomac.2018.06.067 – ident: ref122/cit122 doi: 10.1016/j.plantsci.2014.10.005 – ident: ref103/cit103 doi: 10.1021/acsomega.8b00697 – volume: 25 start-page: 229 issue: 2 year: 2011 ident: ref61/cit61 publication-title: In Vivo – ident: ref130/cit130 doi: 10.1016/j.renene.2018.02.079 – ident: ref133/cit133 doi: 10.1016/j.procbio.2018.05.007 – ident: ref117/cit117 doi: 10.1186/1753-6561-5-S7-P103 – ident: ref4/cit4 doi: 10.3144/expresspolymlett.2009.46 – ident: ref66/cit66 doi: 10.1016/j.ijbiomac.2014.12.044 – ident: ref96/cit96 doi: 10.1097/SS.0b013e3181bf1e03 – ident: ref43/cit43 doi: 10.1021/acs.biomac.0c00695 – ident: ref93/cit93 doi: 10.1016/j.biortech.2005.11.014 – ident: ref15/cit15 doi: 10.1016/j.jobab.2020.04.001 – ident: ref65/cit65 doi: 10.1016/j.biomaterials.2016.12.034 – ident: ref105/cit105 doi: 10.1016/j.indcrop.2007.07.019 – ident: ref47/cit47 doi: 10.1016/j.msec.2019.04.038 – ident: ref3/cit3 doi: 10.11648/j.ijnfs.20140303.16 – ident: ref25/cit25 doi: 10.1111/j.1744-7909.2010.00892.x – ident: ref110/cit110 doi: 10.1016/S1001-0742(08)62296-2 – ident: ref97/cit97 doi: 10.1016/j.biotechadv.2019.107416 – ident: ref102/cit102 doi: 10.3389/fpls.2020.00581 – ident: ref29/cit29 doi: 10.1016/j.indcrop.2016.07.023 – ident: ref111/cit111 doi: 10.1007/s11104-014-2290-7 – ident: ref35/cit35 doi: 10.1016/j.ijbiomac.2019.12.085 – ident: ref140/cit140 doi: 10.3390/catal7120374 – ident: ref92/cit92 doi: 10.1007/s11103-019-00849-3 – ident: ref30/cit30 doi: 10.1063/1.4824019 – ident: ref45/cit45 doi: 10.1016/j.jddst.2017.09.017 – ident: ref38/cit38 doi: 10.1016/j.indcrop.2016.09.046 – ident: ref79/cit79 doi: 10.1080/19476337.2012.688219 – ident: ref27/cit27 doi: 10.1016/j.biortech.2004.02.024 – ident: ref33/cit33 doi: 10.1016/j.ijbiomac.2020.03.016 – ident: ref21/cit21 doi: 10.1002/app.42069 – ident: ref142/cit142 doi: 10.1039/C8GC04059A – ident: ref1/cit1 doi: 10.1016/j.copbio.2018.11.012 – ident: ref116/cit116 doi: 10.1007/s12033-012-9538-3 – ident: ref32/cit32 doi: 10.1039/C4GC01333F – ident: ref80/cit80 doi: 10.1016/j.ijbiomac.2015.01.012 – ident: ref12/cit12 doi: 10.1016/j.pmatsci.2017.12.001 – ident: ref84/cit84 doi: 10.1007/s13399-019-00458-6 – ident: ref89/cit89 doi: 10.1007/s00425-006-0300-6 – volume: 2 start-page: 363 issue: 3 year: 2007 ident: ref99/cit99 publication-title: BioResources doi: 10.15376/biores.2.3.363-370 – ident: ref59/cit59 doi: 10.1271/bbb.100645 – ident: ref136/cit136 doi: 10.1007/s10570-014-0237-z – ident: ref41/cit41 doi: 10.1016/j.ijbiomac.2018.08.109 – ident: ref8/cit8 doi: 10.1016/j.rser.2015.04.091 – ident: ref51/cit51 doi: 10.1371/journal.pone.0035906 – ident: ref37/cit37 doi: 10.1002/app.28097 – volume: 01 start-page: 99 year: 2002 ident: ref107/cit107 publication-title: Chinese Forestry Science and Technology – ident: ref64/cit64 doi: 10.1016/j.ijbiomac.2016.01.109 – ident: ref31/cit31 doi: 10.3390/cosmetics7040085 – ident: ref7/cit7 doi: 10.1016/j.actbio.2021.05.032 – ident: ref49/cit49 doi: 10.1016/j.ijantimicag.2016.08.014 – ident: ref60/cit60 doi: 10.1016/j.antiviral.2007.03.010 – ident: ref124/cit124 doi: 10.1126/science.1227491 – ident: ref75/cit75 doi: 10.1160/TH09-07-0454 – ident: ref9/cit9 doi: 10.1016/j.cbpa.2015.06.009 – ident: ref141/cit141 doi: 10.1021/acssuschemeng.8b02011 – ident: ref113/cit113 doi: 10.3389/fpls.2013.00273 – ident: ref13/cit13 doi: 10.1016/j.jobab.2020.07.002 – ident: ref83/cit83 doi: 10.1016/j.foodchem.2010.10.113 – volume: 109 start-page: 21 issue: 1 year: 1953 ident: ref71/cit71 publication-title: J. Pharmacol. Exp. Ther. – ident: ref90/cit90 doi: 10.1111/j.1365-313X.2009.03996.x – ident: ref78/cit78 doi: 10.1111/jth.13254 – ident: ref120/cit120 doi: 10.3390/ijms14046960 – ident: ref46/cit46 doi: 10.1016/j.jobab.2021.01.002 – ident: ref2/cit2 doi: 10.1016/j.bioactmat.2020.04.007 – ident: ref19/cit19 doi: 10.1039/C5GC01054C – ident: ref134/cit134 doi: 10.1186/s13068-020-1659-5 – ident: ref40/cit40 doi: 10.1016/j.msec.2017.07.054 – ident: ref34/cit34 doi: 10.1111/1541-4337.12322 – ident: ref129/cit129 doi: 10.1002/bbb.1670 – ident: ref53/cit53 doi: 10.1016/0166-3542(91)90039-T – ident: ref69/cit69 doi: 10.1016/j.mehy.2018.09.003 – ident: ref127/cit127 doi: 10.1016/j.jbiotec.2003.09.011 |
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| Snippet | Bioactive substances, displaying excellent biocompatibility, chemical stability, and processability, could be extensively applied in biomedicine and tissue... |
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| SubjectTerms | biocompatibility Biomass Cellulose enzymatic hydrolysis evolution flavonoids human health Humans Hydrolysis lignification lignin Lignin - chemistry medicine plant growth plant pathogens Plants - chemistry terpenoids value added |
| Title | Biological Activities and Emerging Roles of Lignin and Lignin-Based ProductsA Review |
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