Modulation of Lewis Acidity and Steric Parameters in Cyclic Boronates: Copper-Catalyzed Internal-Selective Borylation of Challenging Terminal Alkynes

• Published in: ACS Catalysis Vol. 14; no. 17; pp. 12694 - 12703
• Main Authors: Tsushima, Takumi, Nakamoto, Masaaki, Yoshida, Hiroto
• Format: Journal Article
• Language: English; Japanese
• Published: American Chemical Society 06.09.2024; American Chemical Society (ACS)
• Subjects: copper catalysis; steric properties of cyclic boronate; terminal alkynes; boron-Lewis acidity; diborons; internal selectivity

The installation of a boron functionality into a more substituted carbon of terminal alkynes in copper-catalyzed borylations with diborons is still a challenging subject, primarily due to the intrinsic Lewis acidity of boron moieties such as B­(pin), which typically favor addition to a terminal carb...