Uptake and Biological Effects of Environmentally Relevant Concentrations of the Nonsteroidal Anti-inflammatory Pharmaceutical Diclofenac in Rainbow Trout (Oncorhynchus mykiss)

• Published in: Environmental science & technology Vol. 44; no. 6; pp. 2176 - 2182
• Main Authors: Mehinto, Alvine C, Hill, Elizabeth M, Tyler, Charles R
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 15.03.2010
• Subjects: Animals; Anti-Inflammatory Agents, Non-Steroidal - metabolism; Aquatic ecosystems; Biomarkers - metabolism; Cell cycle; Cyclooxygenase 1 - genetics; Cyclooxygenase 1 - metabolism; Cyclooxygenase 2 - genetics; Cyclooxygenase 2 - metabolism; Cytochrome P-450 CYP1A1 - genetics; Cytochrome P-450 CYP1A1 - metabolism; Diclofenac - metabolism; Dose-Response Relationship, Drug; Ecotoxicology and Human Environmental Health; Environmental science; Female; Gene expression; Gene Expression - drug effects; Genes; Intestines - metabolism; Intestines - pathology; Kidney - metabolism; Kidney - pathology; Liver - metabolism; Nonsteroidal anti-inflammatory drugs; Oncorhynchus mykiss; Oncorhynchus mykiss - metabolism; Pharmaceuticals; RNA, Messenger - metabolism; Trout; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; Water Pollutants, Chemical - metabolism

Diclofenac, a nonsteroidal anti-inflammatory drug, is widely detected in surface waters and can potentially cause deleterious effects in fish. Here, we investigated the biological effects of 21-day exposure to waterborne diclofenac at environmentally relevant concentrations (0, 0.5, 1, 5, and 25 μg/...