Uptake and Biological Effects of Environmentally Relevant Concentrations of the Nonsteroidal Anti-inflammatory Pharmaceutical Diclofenac in Rainbow Trout (Oncorhynchus mykiss) - Mehinto, Alvine C; Hill, Elizabeth M; Tyler, Charles R (Environmental science & technology, 2010)
Keywords: Animals; Anti-Inflammatory Agents, Non-Steroidal - metabolism; Aquatic ecosystems; Biomarkers - metabolism; Cell cycle; Cyclooxygenase 1 - genetics; Cyclooxygenase 1 - metabolism; Cyclooxygenase 2 - genetics; Cyclooxygenase 2 - metabolism; Cytochrome P-450 CYP1A1 - genetics; Cytochrome P-450 CYP1A1 - metabolism; Diclofenac - metabolism; Dose-Response Relationship, Drug; Ecotoxicology and Human Environmental Health; Environmental science; Female; Gene expression; Gene Expression - drug effects; Genes; Intestines - metabolism; Intestines - pathology; Kidney - metabolism; Kidney - pathology; Liver - metabolism; Nonsteroidal anti-inflammatory drugs; Oncorhynchus mykiss; Oncorhynchus mykiss - metabolism; Pharmaceuticals; RNA, Messenger - metabolism; Trout; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; Water Pollutants, Chemical - metabolism