Functionalized Mesoporous Silicas Direct Structural Polymorphism of Amyloid‑β Fibrils

• Published in: Langmuir Vol. 36; no. 26; pp. 7345 - 7355
• Main Authors: Lucas, Michael J, Pan, Henry S, Verbeke, Eric J, Webb, Lauren J, Taylor, David W, Keitz, Benjamin K
• Format: Journal Article
• Language: English
• Published: American Chemical Society 07.07.2020

The aggregation of amyloid-β (Aβ) is associated with the onset of Alzheimer’s disease (AD) and involves a complex kinetic pathway as monomers self-assemble into fibrils. A central feature of amyloid fibrils is the existence of multiple structural polymorphs, which complicates the development of dise...