Detection of Oral Squamous Cell Carcinoma and Cervical Lymph Node Metastasis Using Activatable Near-Infrared Fluorescence Agents

• Published in: Archives of otolaryngology--head & neck surgery Vol. 137; no. 6; pp. 609 - 615
• Main Authors: Keereweer, Stijn, Mieog, J. Sven D, Mol, Isabel M, Van Driel, Pieter B. A. A, Snoeks, Thomas J. A, Baatenburg de Jong, Robert J, Vahrmeijer, Alexander L, Kerrebijn, Jeroen D. F, Löwik, Clemens W. G. M
• Format: Journal Article
• Language: English
• Published: Chicago, IL American Medical Association 01.06.2011
• Subjects: Animals; Biological and medical sciences; Carcinoma, Squamous Cell - pathology; Cell Line, Tumor; Cells; Feasibility Studies; Female; Fluorescence; Hematologic and hematopoietic diseases; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Luciferases; Luminescent Agents; Lymph Nodes - pathology; Lymphatic Metastasis; Medical sciences; Metastasis; Mice; Mice, Nude; Oral cancer; Otolaryngology; Otorhinolaryngology. Stomatology; Random Allocation; Rodents; Spectroscopy, Near-Infrared; Tongue; Tongue Neoplasms - pathology; Transfection; Tumors; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology; Stomatology; Fluorescence; Malignant lymphadenopathy; Malignant hemopathy; Oral cavity disease; Malignant tumor; Oral squamous cell carcinoma; Cancer; Cervical lymph node metastasis

OBJECTIVE To assess the feasibility of optical imaging using activatable near-infrared fluorescence (NIRF) agents to detect oral cancer and cervical lymph node metastasis in vivo. DESIGN In vivo study. SETTING University medical center. SUBJECTS Female nude mice aged 4 to 6 weeks. INTERVENTION Lucif...