Leaderless mRNAs in the Spotlight: Ancient but Not Outdated

• Published in: Microbiology spectrum Vol. 6; no. 4
• Main Authors: Beck, Heather J, Moll, Isabella
• Format: Journal Article
• Language: English
• Published: United States ASM Press 01.07.2018
• Subjects: 5' Untranslated Regions; Archaea; Archaea - genetics; Archaea - metabolism; Bacteria; Bacteria - genetics; Bacteria - metabolism; Bacterial Genetics, Cell Biology, Physiology; Base Sequence; Codon, Initiator; Gene Expression Regulation, Archaeal - physiology; Gene Expression Regulation, Bacterial - physiology; Ribosomal Proteins; RNA, Bacterial; RNA, Bacterial - physiology; RNA, Messenger; RNA, Messenger - physiology; Stress, Psychological; Transcriptome

Previously, leaderless mRNAs (lmRNAs) were perceived to make up only a minor fraction of the transcriptome in bacteria. However, advancements in RNA sequencing technology are uncovering vast numbers of lmRNAs, particularly in archaea, , and extremophiles and thus underline their significance in cell...