Chlorogenic Acid Alleviates Chronic Stress-Induced Intestinal Damage by Inhibiting the P38MAPK/NF-κB Pathway

• Published in: Journal of agricultural and food chemistry Vol. 71; no. 24; pp. 9381 - 9390
• Main Authors: Zhao, Yuan, Wang, Chaoran, Yang, Tianyuan, Feng, Guofeng, Tan, Haoyang, Piao, Xue, Chen, Dongni, Zhang, Yu, Jiao, Wenjign, Chen, Yongping, Sha, Jichen, Fan, Honggang
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 21.06.2023
• Subjects: Animals; Bioactive Constituents, Metabolites, and Functions; Chlorogenic Acid; food chemistry; gene expression; intestines; intraperitoneal injection; NF-kappa B - metabolism; occludins; p38 Mitogen-Activated Protein Kinases - genetics; polyphenols; Rats; Rats, Wistar; tight junctions; Tumor Necrosis Factor-alpha; NF-κB; chronic stress; intestinal barrier; chlorogenic acid; P38MAPK

Chronic stress can cause intestinal barrier damage. MAPK and NF-κB are closely related to it. Chlorogenic acid (CGA), a dietary polyphenol, has been shown to have intestinal protective effects, but whether by regulating MAPK and NF-κB is not known. Therefore, in this experiment, 24 Wistar rats were...