Free Fatty Acids Induce Apoptosis of Mammary Epithelial Cells of Ketotic Dairy Cows via the Mito-ROS/NLRP3 Signaling Pathway

• Published in: Journal of agricultural and food chemistry Vol. 71; no. 34; pp. 12645 - 12656
• Main Authors: Chang, Renxu, Jia, Hongdou, Dong, Zhihao, Xu, Qiushi, Liu, Lei, Majigsuren, Zolzaya, Batbaatar, Tugsjargal, Xu, Chuang, Yang, Qing, Sun, Xudong
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 30.08.2023
• Subjects: Agricultural and Environmental Chemistry; Animals; apoptosis; Apoptosis - drug effects; Cattle; early lactation; epithelial cells; Epithelial Cells - cytology; Epithelial Cells - drug effects; Epithelial Cells - metabolism; epithelium; Fatty Acids, Nonesterified - pharmacology; Female; food chemistry; inflammasomes; Inflammasomes - metabolism; inflammation; ketosis; Ketosis - drug therapy; Ketosis - metabolism; mammary glands; Mammary Glands, Animal; milk yield; mitochondria; Mitochondria - metabolism; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; oligomerization; reactive oxygen species; Signal Transduction - drug effects; NLRP3; apoptosis; bovine mammary epithelial cells; Mito-ROS

Early lactation increases metabolic stress in ketotic dairy cows, leading to mitochondrial damage, apoptosis, and inflammatory response in mammary epithelial cells. The pyrin domain 3 (NLRP3) pathway involving the mitochondrial reactive oxygen species (Mito-ROS)-induced nucleotide-binding oligomeriz...