Ursolic Acid, a Novel Liver X Receptor α (LXRα) Antagonist Inhibiting Ligand-Induced Nonalcoholic Fatty Liver and Drug-Induced Lipogenesis - Lin, Yen-Ning; Wang, Charles C. N; Chang, Hsiao-Yun; Chu, Fang-Yi; Hsu, Yu-An; Cheng, Wai-Kok; Ma, Wei-Chih; Chen, Chao-Jung; Wan, Lei; Lim, Yun-Ping (Journal of agricultural and food chemistry, 2018)
Keywords: agonists; AMP-activated protein kinase; animal models; Animals; antagonists; atherosclerosis; Basic-Leucine Zipper Transcription Factors - genetics; Basic-Leucine Zipper Transcription Factors - metabolism; cholesterol; computer simulation; excretion; fatty liver; genes; homeostasis; Humans; Hydrocarbons, Fluorinated - administration & dosage; Hydrocarbons, Fluorinated - chemistry; hyperlipidemia; intestines; leucine zipper; Ligands; lipid content; lipogenesis; Lipogenesis - drug effects; liver; Liver - drug effects; Liver - metabolism; Liver X Receptors - antagonists & inhibitors; Liver X Receptors - chemistry; Liver X Receptors - genetics; Liver X Receptors - metabolism; Male; messenger RNA; Mice; Mice, Inbred C57BL; Molecular Docking Simulation; Non-alcoholic Fatty Liver Disease - drug therapy; Non-alcoholic Fatty Liver Disease - genetics; Non-alcoholic Fatty Liver Disease - metabolism; phosphorylation; pregnanes; promoter regions; protein synthesis; steroid receptors; Sterol Regulatory Element Binding Protein 1 - genetics; Sterol Regulatory Element Binding Protein 1 - metabolism; Sulfonamides - administration & dosage; Sulfonamides - chemistry; therapeutics; transcriptional activation; Triterpenes - administration & dosage; Triterpenes - chemistry; Ursolic Acid; nonalcoholic fatty liver disease; pregnane X receptor; liver X receptor α; ursolic acid