Pathogenic Mechanisms of Depression in Multiple Sclerosis

This article reviews various theories and findings on mechanisms of depression in MS, describing the latest research approaches, as they relate to theories of disease-process. The authors have compiled data on lesion location, extensity, and severity; the effects of immune dysfunction and side effec...

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Published inThe journal of neuropsychiatry and clinical neurosciences Vol. 23; no. 3; pp. 261 - 276
Main Authors Vattakatuchery, Joe John, Rickards, Hugh, Cavanna, Andrea Eugenio
Format Journal Article
LanguageEnglish
Published Arlington, VA American Psychiatric Publishing, Inc 01.07.2011
American Psychiatric Publishing
Subjects
Adult and adolescent clinical studies
Biological and medical sciences
Depression
Medical sciences
Mood disorders
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Mood disorder
Depression
Nervous system diseases
Multiple sclerosis
Central nervous system disease
Inflammatory disease
Online AccessGet full text
ISSN0895-0172
1545-7222
DOI10.1176/jnp.23.3.jnp261

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Abstract This article reviews various theories and findings on mechanisms of depression in MS, describing the latest research approaches, as they relate to theories of disease-process. The authors have compiled data on lesion location, extensity, and severity; the effects of immune dysfunction and side effects of immunomodulatory drugs, including interferon therapy; and psychosocial stressors as they all relate to the common symptom of depression in MS. Patients with multiple sclerosis (MS) have an increased risk of developing depression as compared with healthy subjects and patients with many other chronic neurological conditions. The observation that depressive symptoms can precede the onset of neurological symptoms suggests that depression may be related to early disease-specific processes. Several pathogenic mechanisms have been proposed to explain the etiology of depression in patients with MS. This article reviews the current evidence for the contribution of lesional, autoimmune, iatrogenic, and psychosocial factors. It appears that the etiology of depression is multifactorial and varies in individual patients with MS.
AbstractList Patients with multiple sclerosis (MS) have an increased risk of developing depression as compared with healthy subjects and patients with many other chronic neurological conditions. The observation that depressive symptoms can precede the onset of neurological symptoms suggests that depression may be related to early disease-specific processes. Several pathogenic mechanisms have been proposed to explain the etiology of depression in patients with MS. This article reviews the current evidence for the contribution of lesional, autoimmune, iatrogenic, and psychosocial factors. It appears that the etiology of depression is multifactorial and varies in individual patients with MS.
This article reviews various theories and findings on mechanisms of depression in MS, describing the latest research approaches, as they relate to theories of disease-process. The authors have compiled data on lesion location, extensity, and severity; the effects of immune dysfunction and side effects of immunomodulatory drugs, including interferon therapy; and psychosocial stressors as they all relate to the common symptom of depression in MS. Patients with multiple sclerosis (MS) have an increased risk of developing depression as compared with healthy subjects and patients with many other chronic neurological conditions. The observation that depressive symptoms can precede the onset of neurological symptoms suggests that depression may be related to early disease-specific processes. Several pathogenic mechanisms have been proposed to explain the etiology of depression in patients with MS. This article reviews the current evidence for the contribution of lesional, autoimmune, iatrogenic, and psychosocial factors. It appears that the etiology of depression is multifactorial and varies in individual patients with MS.
Author Vattakatuchery, Joe John
Rickards, Hugh
Cavanna, Andrea Eugenio
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Keywords Mood disorder
Depression
Nervous system diseases
Multiple sclerosis
Central nervous system disease
Inflammatory disease
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Snippet This article reviews various theories and findings on mechanisms of depression in MS, describing the latest research approaches, as they relate to theories of...
Patients with multiple sclerosis (MS) have an increased risk of developing depression as compared with healthy subjects and patients with many other chronic...
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SubjectTerms Adult and adolescent clinical studies
Biological and medical sciences
Depression
Medical sciences
Mood disorders
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Title Pathogenic Mechanisms of Depression in Multiple Sclerosis
URI http://dx.doi.org/10.1176/jnp.23.3.jnp261
https://www.proquest.com/docview/916301254
https://www.proquest.com/docview/902381735
Volume 23
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