Synthesis of Arylethylamines via C(sp3)–C(sp3) Palladium-Catalyzed Cross-Coupling

• Published in: Journal of organic chemistry Vol. 86; no. 4; pp. 3583 - 3604
• Main Authors: Lippa, Rhys A, Battersby, David J, Murphy, John A, Barrett, Tim N
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 19.02.2021; Amer Chemical Soc
• Subjects: agrochemicals; Chemistry; Chemistry, Organic; cross-coupling reactions; organic chemistry; Physical Sciences; reaction mechanisms; Science & Technology

Substituted arylethylamines represent a key structural motif in natural, pharmaceutical, and agrochemical compounds. Access to such scaffolds has been the subject of long-standing synthetic interest. Herein, we report the synthesis of such scaffolds via a palladium-catalyzed C­(sp3)–C­(sp3) coupling...