Catalytic 2‑Ethylhexanoic Acid Promotes Mild Miyaura Borylations

• Published in: Journal of organic chemistry Vol. 89; no. 8; pp. 5901 - 5904
• Main Authors: Klootwyk, Brittany M., Ruble, J. Craig, Cumming, Graham R., Woerly, Eric M.
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 19.04.2024; Amer Chemical Soc
• Subjects: carboxylic acids; Chemistry; Chemistry, Organic; heterocyclic compounds; organic chemistry; Physical Sciences; potassium; potassium carbonate; Science & Technology; stoichiometry; CROSS-COUPLING REACTION; HALOARENES; ARYL CHLORIDES

The Miyaura borylation of aryl and heteroaryl chlorides and bromides using a combination of potassium carbonate and 5 mol % 2-ethylhexanoic acid at 25 °C is reported. The in situ generation of a catalytic amount of potassium 2-ethylhexanoate under these conditions avoids the need for special handlin...