Carbamazepine-10,11-Epoxide in Epilepsy A Pilot Study
• The effects of carbamazepine-10,11-epoxide, an active metabolite of carbamazepine, were evaluated in seven outpatients with frequent epileptic seizures. The study included an initial 4-week period with the carbamazepine dose optimized for each patient. Patients were then crossed over, dose by dose...
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Published in | Archives of neurology (Chicago) Vol. 47; no. 8; pp. 888 - 892 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Chicago, IL
American Medical Association
01.08.1990
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Subjects | |
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Abstract | • The effects of carbamazepine-10,11-epoxide, an active metabolite of carbamazepine, were evaluated in seven outpatients with frequent epileptic seizures. The study included an initial 4-week period with the carbamazepine dose optimized for each patient. Patients were then crossed over, dose by dose, to carbamazepine-10,11-epoxide and followed up for another 4 weeks. Dosing was single blind. The evaluation of the anticonvulsant effect was hampered by marked fluctuations in plasma levels during treatment with carbamazepine-10,11-epoxide. There was, however, no significant change in seizure control. During epoxide treatment, no subjective side effects were reported despite epoxide plasma concentrations up to 57 μmol/L. Neuropsychological assessment revealed a significant improvement in finger motor speed and logical reasoning during the carbamazepine-10,11-epoxide period. Subnormal serum sodium levels in two patients were normalized after switching from carbamazepine to the epoxide. Continued investigations with this active metabolite of carbamazepine in epilepsy are therefore justified. |
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AbstractList | • The effects of carbamazepine-10,11-epoxide, an active metabolite of carbamazepine, were evaluated in seven outpatients with frequent epileptic seizures. The study included an initial 4-week period with the carbamazepine dose optimized for each patient. Patients were then crossed over, dose by dose, to carbamazepine-10,11-epoxide and followed up for another 4 weeks. Dosing was single blind. The evaluation of the anticonvulsant effect was hampered by marked fluctuations in plasma levels during treatment with carbamazepine-10,11-epoxide. There was, however, no significant change in seizure control. During epoxide treatment, no subjective side effects were reported despite epoxide plasma concentrations up to 57 μmol/L. Neuropsychological assessment revealed a significant improvement in finger motor speed and logical reasoning during the carbamazepine-10,11-epoxide period. Subnormal serum sodium levels in two patients were normalized after switching from carbamazepine to the epoxide. Continued investigations with this active metabolite of carbamazepine in epilepsy are therefore justified. The effects of carbamazepine-10,11-epoxide, an active metabolite of carbamazepine, were evaluated in seven outpatients with frequent epileptic seizures. The study included an initial 4-week period with the carbamazepine dose optimized for each patient. Patients were then crossed over, dose by dose, to carbamazepine-10,11-epoxide and followed up for another 4 weeks. Dosing was single blind. The evaluation of the anticonvulsant effect was hampered by marked fluctuations in plasma levels during treatment with carbamazepine-10,11-epoxide. There was, however, no significant change in seizure control. During epoxide treatment, no subjective side effects were reported despite epoxide plasma concentrations up to 57 mumol/L. Neuropsychological assessment revealed a significant improvement in finger motor speed and logical reasoning during the carbamazepine-10,11-epoxide period. Subnormal serum sodium levels in two patients were normalized after switching from carbamazepine to the epoxide. Continued investigations with this active metabolite of carbamazepine in epilepsy are therefore justified. |
Author | Svensson, Jan-Olof Nilsson, Bengt Y Almkvist, Ove Tomson, Torbjörn Bertilsson, Leif |
Author_xml | – sequence: 1 givenname: Torbjörn surname: Tomson fullname: Tomson, Torbjörn – sequence: 2 givenname: Ove surname: Almkvist fullname: Almkvist, Ove – sequence: 3 givenname: Bengt Y surname: Nilsson fullname: Nilsson, Bengt Y – sequence: 4 givenname: Jan-Olof surname: Svensson fullname: Svensson, Jan-Olof – sequence: 5 givenname: Leif surname: Bertilsson fullname: Bertilsson, Leif |
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Keywords | Human Chemotherapy Nervous system diseases Treatment Convulsion Metabolite Epilepsy HPLC chromatography Anticonvulsant Metabolism Pharmacokinetics |
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SubjectTerms | Adult Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Carbamazepine - analogs & derivatives Carbamazepine - blood Carbamazepine - therapeutic use Dose-Response Relationship, Drug Epilepsy - blood Epilepsy - drug therapy Female Humans Male Medical sciences Middle Aged Neuropharmacology Neuropsychological Tests Pharmacology. Drug treatments Pilot Projects Single-Blind Method |
Title | Carbamazepine-10,11-Epoxide in Epilepsy A Pilot Study |
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