Nuciferine Inhibits TMEM16A in Dietary Adjuvant Therapy for Lung Cancer

• Published in: Journal of agricultural and food chemistry Vol. 70; no. 12; pp. 3687 - 3696
• Main Authors: Bai, Xue, Liu, Xinyi, Li, Shuting, An, Hailong, Kang, Xianjiang, Guo, Shuai
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 30.03.2022
• Subjects: active ingredients; adjuvants; antineoplastic activity; apoptosis; Aporphines - pharmacology; Aporphines - therapeutic use; Bioactive Constituents, Metabolites, and Functions; cancer therapy; Cell Proliferation; cisplatin; food chemistry; functional foods; Humans; intragastric administration; leaves; lung neoplasms; Lung Neoplasms - drug therapy; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; morbidity; mortality; neoplasm cells; pharmacokinetics; Signal Transduction; site-directed mutagenesis; toxicity; Western blotting; nuciferine; lung cancer; adjuvant therapy; functional food; TMEM16A

Lung cancer is a malignant tumor with the highest morbidity and mortality rates. Food therapy is a common adjuvant treatment for lung cancer due to its safety and painlessness. Developing new functional food and exploring novel drug targets is important for lung cancer adjuvant therapy. This study c...