Usefulness of Upper Airway Endoscopy in the Evaluation of Pediatric Pulmonary Aspiration

• Published in: JAMA otolaryngology-- head & neck surgery Vol. 142; no. 4; p. 339
• Main Authors: Adil, Eelam, Gergin, Ozgul, Kawai, Kosuke, Rahbar, Reza, Watters, Karen
• Format: Journal Article
• Language: English
• Published: United States 01.04.2016
• Subjects: Adolescent; Adult; Bronchoscopy - utilization; Child; Child, Preschool; Diagnosis, Differential; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; Laryngomalacia - diagnosis; Laryngomalacia - etiology; Laryngomalacia - therapy; Laryngoscopy - utilization; Laryngostenosis - diagnosis; Laryngostenosis - etiology; Laryngostenosis - therapy; Lung Diseases - diagnosis; Lung Diseases - etiology; Lung Diseases - therapy; Male; Reproducibility of Results; Respiratory Aspiration - complications; Respiratory Aspiration - diagnosis; Respiratory Aspiration - therapy; Retrospective Studies; Time Factors; Tracheomalacia - diagnosis; Tracheomalacia - etiology; Tracheomalacia - therapy; Young Adult
• DOI: 10.1001/jamaoto.2015.3923

There is no consensus on the evaluation of pediatric patients with aspiration. To determine the yield of direct laryngoscopy and bronchoscopy (DLB) using general anesthesia in pediatric patients who aspirate and to identify clinical predictors of aspiration-related airway lesions. Retrospective review at a tertiary referral children's hospital. A medical record review was performed on all patients with a documented diagnosis of pulmonary aspiration who underwent DLB using general anesthesia during a 5-year period (January 2010 to December 2014). Direct laryngoscopy and bronchoscopy using general anesthesia. Data were collected and analyzed, including age, sex, history of intubation, flexible laryngoscopy results, DLB findings, recurrent pneumonia, and associated diagnoses. Five hundred thirty-two patients met the inclusion criteria. Their mean (SD) age was 2.2 (3.6) years (age range, 0.1-25.0 years), with more than half younger than 1 year. Sixty-two percent (328 of 532) of the participants were male. Flexible laryngoscopy examination alone identified 93 patients with an airway lesion. Direct laryngoscopy and bronchoscopy identified 173 additional diagnoses and had a greater diagnostic yield for airway lesions (45.1% [240 of 532]) than flexible laryngoscopy examination alone (P < .001). Patients with an aspiration-related airway lesion were older (mean [SD] age, 2.7 [3.8] vs 2.2 [3.8] years; P = .02) and more likely to have another aerodigestive disorder than were patients without an airway lesion (21.7% vs 11.6%; P = .004). Older age (adjusted risk ratio [95% CI], 1.37 [1.08-1.73]; P = .01), recurrent pneumonia (1.40 [1.11-1.76]; P = .004), and history of intubation (1.35 [1.07-1.70]; P = .01) were significantly associated with the presence of an aspiration-related airway lesion in the multivariable model. Patients with an aspiration-related airway lesion were less likely to have neurologic disease than were patients without an airway lesion (0.50 [0.34-0.73]; P < .001). In all, 66.3% of patients (110 of 166) eventually underwent surgical repair of an identified aspiration-related airway lesion. In children with chronic aspiration who warrant further evaluation, flexible laryngoscopy alone is not sufficient. There is a high incidence of aspiration-related airway lesions identified on DLB and not seen on flexible laryngoscopy, with 66.3% (110 of 166) of those lesions eventually requiring surgical intervention. Patients 1 year or older with a history of recurrent pneumonia or intubation are more likely to have an aspiration-related airway lesion.