Mechano-Responsive, Tough, and Antibacterial Zwitterionic Hydrogels with Controllable Drug Release for Wound Healing Applications

• Published in: ACS applied materials & interfaces Vol. 12; no. 47; pp. 52307 - 52318
• Main Authors: Fang, Kun, Wang, Rong, Zhang, Hua, Zhou, Linjie, Xu, Ting, Xiao, Ying, Zhou, Yang, Gao, Guorong, Chen, Jing, Liu, Donglei, Ai, Fanrong, Fu, Jun
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 25.11.2020
• Subjects: adhesion; Adhesiveness; adsorption; Animals; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - metabolism; Anti-Bacterial Agents - pharmacology; antibacterial properties; antibiotics; Bandages; biocompatibility; Biocompatible Materials - chemistry; Biocompatible Materials - pharmacology; Biocompatible Materials - therapeutic use; Biological and Medical Applications of Materials and Interfaces; Cell Survival - drug effects; Compressive Strength; deformation; Gram-Negative Bacteria - drug effects; Gram-Positive Bacteria - drug effects; hydrogels; Hydrogels - chemistry; Hydrogels - pharmacology; Hydrogels - therapeutic use; hydrophobicity; Male; Mice; Micelles; Poloxamer - chemistry; Rabbits; Skin Diseases - drug therapy; Skin Diseases - pathology; skin irritation; sulfobetaine; Tensile Strength; therapeutics; Wound Healing - drug effects; zwitterions; tough hydrogels; antibacterial; drug release; mechano-responsive; antifouling

Acute wounds subject to frequent deformations are difficult to be treated because the healing process was easily interfered by external mechanical forces. Traditional wound dressings have limited efficacy because of their poor mechanical properties and skin adhesiveness and difficulty in the deliver...