Crohn’s Disease Is Associated with Decreased CYP3A4 and P‑Glycoprotein Protein Expression

• Published in: Molecular pharmaceutics Vol. 16; no. 9; pp. 4059 - 4064
• Main Authors: Wilson, Aze, Urquhart, Bradley L, Ponich, Terry, Chande, Nilesh, Gregor, James C, Beaton, Melanie, Kim, Richard B
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 03.09.2019
• Subjects: P-glycoprotein; intestinal protein expression; CYP3A4; Crohn’s disease

Cytochrome P450 (CYP) 3A4 and P-glycoprotein (P-gp) have broad substrate overlap and are involved in the metabolism and transport of nearly 50% of currently prescribed medications. In the intestine, CYP3A4 and P-gp are coexpressed in the enterocytes at the intestinal villous tip and act in a coordin...