Polymeric Chloroquine as an Effective Antimigration Agent in the Treatment of Pancreatic Cancer

• Published in: Molecular pharmaceutics Vol. 19; no. 12; pp. 4631 - 4643
• Main Authors: Khan, Rubayat, Panja, Sudipta, Ding, Ling, Tang, Siyuan, Tang, Weimin, Kapoor, Ekta, Bennett, Robert G., Oupický, David
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 05.12.2022
• Subjects: Antineoplastic Agents - therapeutic use; Chloroquine - pharmacology; Chloroquine - therapeutic use; Humans; Hydroxychloroquine - pharmacology; Hydroxychloroquine - therapeutic use; Pancreatic Neoplasms; Pancreatic Neoplasms - drug therapy; Polymers - therapeutic use; cancer cell migration; pancreatic cancer; Hydroxychloroquine; polymeric drugs; metastasis; intraperitoneal administration

Hydroxychloroquine (HCQ) has been the subject of multiple recent preclinical and clinical studies for its beneficial use in the combination treatments of different types of cancers. Polymeric HCQ (PCQ), a macromolecular multivalent version of HCQ, has been shown to be effective in various cancer mod...