Characterization of Bile Acid Sulfate Conjugates as Substrates of Human Organic Anion Transporting Polypeptides

• Published in: Molecular pharmaceutics Vol. 20; no. 6; pp. 3020 - 3032
• Main Authors: Orozco, Christine C., Neuvonen, Mikko, Bi, Yi-An, Cerny, Matthew A., Mathialagan, Sumathy, Tylaska, Laurie, Rago, Brian, Costales, Chester, King-Ahmad, Amanda, Niemi, Mikko, Rodrigues, A. David
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 05.06.2023
• Subjects: Bile Acids and Salts; Biological Transport - physiology; Biomarkers - metabolism; Humans; Liver-Specific Organic Anion Transporter 1 - genetics; Liver-Specific Organic Anion Transporter 1 - metabolism; Organic Anion Transporters - genetics; Organic Anion Transporters - metabolism; Organic Anion Transporters, Sodium-Independent - metabolism; Solute Carrier Organic Anion Transporter Family Member 1B3 - metabolism; Sulfates; sulfated bile acids; organic anion transporting polypeptide; biomarker; drug interaction

Drug interactions involving the inhibition of hepatic organic anion transporting polypeptides (OATPs) 1B1 and OATP1B3 are considered important. Therefore, we sought to study various sulfated bile acids (BA-S) as potential clinical OATP1B1/3 biomarkers. It was determined that BA-S [e.g., glycochenode...