Use of Gastrointestinal Simulator, Mass Transport Analysis, and Absorption Simulation to Investigate the Impact of pH Modifiers in Mitigating Weakly Basic Drugs’ Performance Issues Related to Gastric pH: Palbociclib Case Study - Kuminek, Gislaine; Salehi, Niloufar; Waltz, Nicholas M.; Sperry, David C.; Greenwood, Dale E.; Hate, Siddhi S.; Amidon, Gregory E. (Molecular pharmaceutics, 2023)
Keywords: Administration, Oral; Computer Simulation; Humans; Hydrogen-Ion Concentration; Intestinal Absorption - physiology; Models, Biological; Pharmaceutical Preparations; Reducing Agents - pharmacology; Solubility; mass transport model; dissolution modeling; gastrointestinal simulator; pH modifier; palbociclib