Improving Dissolution Behavior and Oral Absorption of Drugs with pH-Dependent Solubility Using pH Modifiers: A Physiologically Realistic Mass Transport Analysis - Salehi, Niloufar; Kuminek, Gislaine; Al-Gousous, Jozef; Sperry, David C; Greenwood, Dale E; Waltz, Nicholas M; Amidon, Gordon L; Ziff, Robert M; Amidon, Gregory E (Molecular pharmaceutics, 2021)
Keywords: Administration, Oral; Betaine - pharmacology; Biological Availability; Chemistry, Pharmaceutical; Computer Simulation; Drug Design; Drug Liberation; Excipients - pharmacology; Fumarates - pharmacology; Gastrointestinal Absorption - drug effects; Humans; Hydrogen-Ion Concentration - drug effects; Models, Biological; Solubility; Tartrates - pharmacology; mass transport model; surface solubility; hierarchical mass transfer model; surface pH; dissolution modeling; pH modifier; proton pump inhibitor; achlorhydria; diffusion layer model; H2 blockers; gastrointestinal simulator; physiological mass transfer model; elevated gastric pH; H2 antagonists