Maintaining Supersaturation of Nimodipine by PVP with or without the Presence of Sodium Lauryl Sulfate and Sodium Taurocholate

• Published in: Molecular pharmaceutics Vol. 15; no. 7; pp. 2754 - 2763
• Main Authors: Pui, Yipshu, Chen, Yuejie, Chen, Huijun, Wang, Shan, Liu, Chengyu, Tonnis, Wouter, Chen, Linc, Serno, Peter, Bracht, Stefan, Qian, Feng
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 02.07.2018
• Subjects: sodium taurocholate; sodium lauryl sulfate; supersaturation; nimodipine; surfactant; amorphous solid dispersion

Amorphous solid dispersion (ASD) is one of the most versatile supersaturating drug delivery systems to improve the dissolution rate and oral bioavailability of poorly water-soluble drugs. PVP based ASD formulation of nimodipine (NMD) has been marketed and effectively used in clinic for nearly 30 yea...