Charge-Reversible Pro-Ribonuclease Enveloped in Virus-like Synthetic Nanocapsules for Systemic Treatment of Intractable Glioma

• Published in: ACS applied materials & interfaces Vol. 14; no. 27; pp. 30493 - 30506
• Main Authors: Cui, Hongyan, Zhang, Liuwei, Zeng, Shuang, Wang, Yu, Li, Zhen, Wang, Jingyun, Chen, Qixian
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 13.07.2022
• Subjects: anhydrides; Biological and Medical Applications of Materials and Interfaces; carboxylation; crosslinking; cytosol; cytotoxicity; decarboxylation; disulfides; endocytosis; glioma; glutathione; ligands; manufacturing; metalloproteinases; nanocapsules; ribonucleases; therapeutics; thiols; transportation; virus-like; redox-responsive; pro-protein; MMP-2; protein delivery; pH-responsive

We have tailored multifaceted chemistries into the manufacture of artificial virus-like delivery vehicles mimicking viral “intelligent” transportation pathways through sequential biological barriers; these vehicles can acquire the ability to dynamically “program transfer” to their target sites. To a...