CYP2B6 18492T→C Polymorphism Compromises Efavirenz Concentration in Coinfected HIV and Tuberculosis Patients Carrying CYP2B6 Haplotype 1/1

• Published in: Antimicrobial agents and chemotherapy Vol. 58; no. 4; pp. 2268 - 2273
• Main Authors: MANOSUTHI, Weerawat, SUKASEM, Chonlaphat, THONGYEN, Supeda, NILKAMHANG, Samruay, MANOSUTHI, Sukanya, SUNGKANUPARPH, Somnuek
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 2014
• Subjects: Adult; Anti-HIV Agents - pharmacokinetics; Anti-HIV Agents - therapeutic use; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral Agents; Aryl Hydrocarbon Hydroxylases; Aryl Hydrocarbon Hydroxylases - genetics; Bacterial diseases; Benzoxazines; Benzoxazines - pharmacokinetics; Benzoxazines - therapeutic use; Biological and medical sciences; Coinfection; Cytochrome P-450 CYP2B6; Female; Haplotypes - genetics; HIV Infections; HIV Infections - blood; HIV Infections - drug therapy; Human bacterial diseases; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infectious diseases; Male; Medical sciences; Middle Aged; Pharmacology. Drug treatments; Polymorphism, Single Nucleotide - genetics; Reverse Transcriptase Inhibitors; Reverse Transcriptase Inhibitors - pharmacokinetics; Reverse Transcriptase Inhibitors - therapeutic use; Tuberculosis; Tuberculosis - blood; Tuberculosis - drug therapy; Tuberculosis and atypical mycobacterial infections; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Antiretroviral agent; Benzoxazine derivatives; RNA-directed DNA polymerase; Mixed infection; Genetic variability; Acetylenic compound; Isozyme; Non nucleoside compound; Mycobacterial infection; Efavirenz; Reverse transcriptase inhibitor; Antiviral; Haplotype; Human; Immunopathology; Enzyme; Transferases; Cytochrome P450; Enzyme inhibitor; Genotype; AIDS; Concentration; Immune deficiency; Infection; Allosteric inhibitor; Nucleotidyltransferases; Tuberculosis; Viral disease; Bacteriosis; Polymorphism; Cytochrome P450 2B6

Data regarding the effect of the CYP2B6 18492T→C polymorphism on plasma efavirenz concentrations and 96-week virologic responses in patients coinfected with HIV and tuberculosis (TB) are still unavailable. A total of 139 antiretroviral-naive HIV-infected adults with active TB were prospectively enro...