Efficient and Selective Biosynthesis of a Precursor-Directed FK506 Analogue: Paving the Way for Click Chemistry - Goranovič, Dušan; Jenko, Branko; Ramšak, Barbara; Podgoršek Berke, Ajda; Bedrač, Leon; Horvat, Jaka; Šala, Martin; Makuc, Damjan; Carriche, Guilhermina M.; Silva, Luana; Lopez Krol, Aleksandra; Pšeničnik, Alen; et al. (Journal of natural products (Washington, D.C.), 2025)
Keywords: biosynthesis; carbon; Click Chemistry; cytotoxicity; domain; Humans; immunosuppression; immunosuppressive agents; Immunosuppressive Agents - chemistry; Immunosuppressive Agents - pharmacology; moieties; Molecular Structure; nonribosomal peptides; Peptide Synthases - metabolism; polyketide synthases; Polyketide Synthases - metabolism; polyketides; Tacrolimus - analogs & derivatives; Tacrolimus - chemistry; Tacrolimus - metabolism