Total Synthesis and Comparative Evaluation of Luzopeptin A−C and Quinoxapeptin A−C

• Published in: Journal of the American Chemical Society Vol. 121; no. 49; pp. 11375 - 11383
• Main Authors: Boger, Dale L, Ledeboer, Mark W, Kume, Masaharu, Searcey, Mark, Jin, Qing
• Format: Journal Article
• Language: English
• Published: American Chemical Society 15.12.1999

Full details of the total syntheses of luzopeptin A−C and quinoxapeptin A−C, C 2-symmetric cyclic depsidecapeptides bearing two pendant heterocyclic chromophores, are disclosed and serve to establish the quinoxapeptin relative and absolute configuration. Key elements of the approach include the late...