Thyroid-Disrupting Effects of Exposure to Fipronil and Its Metabolites from Drinking Water Based on Human Thyroid Follicular Epithelial Nthy-ori 3‑1 Cell Lines

Fipronil is a broad-spectrum insecticide used for plants and poultry. Owing to its widespread use, fipronil and its metabolites (fipronil sulfone, fipronil desulfinyl, and fipronil sulfide), termed FPM, can be frequently detected in drinking water and food. Fipronil can affect the thyroid function o...

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Published inEnvironmental science & technology Vol. 57; no. 15; pp. 6072 - 6084
Main Authors Zhuang, Jianhui, Jiang, Zhiqiang, Chen, Dawei, Li, Jingguang, Crabbe, M. James C., Qiu, Meiyue, Zheng, Yuxin, Qu, Weidong
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 18.04.2023
Subjects
Animals
Biomarkers
Cell Line
Cell lines
Child
Cytotoxicity
Disruption
Drinking water
Drinking Water - metabolism
Ecotoxicology and Public Health
Fipronil
Heme
Hormones
Humans
Insecticides
Iodide peroxidase
Iodides
Metabolites
NF-E2-Related Factor 2 - metabolism
NF-E2-Related Factor 2 - pharmacology
Oxidative stress
Oxygenase
Peroxidase
Pesticides
River basins
Thyrocytes
Thyroid
Thyroid Epithelial Cells
Thyroid gland
Thyroid Gland - metabolism
Thyroid hormones
Thyroxine
thyroid-disrupting effects
Nthy-ori 3-1 cells
tetraiodothyronine
fipronil metabolites
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Abstract Fipronil is a broad-spectrum insecticide used for plants and poultry. Owing to its widespread use, fipronil and its metabolites (fipronil sulfone, fipronil desulfinyl, and fipronil sulfide), termed FPM, can be frequently detected in drinking water and food. Fipronil can affect the thyroid function of animals, but the effects of FPM on the human thyroid remain unclear. We employed human thyroid follicular epithelial Nthy-ori 3-1 cells to examine combined cytotoxic responses, thyroid-related functional proteins including the sodium-iodide symporter (NIS), thyroid peroxidase (TPO), deiodinases I–III (DIO I–III), and the nuclear factor erythroid-derived factor 2–related factor 2 (NRF2) pathway induced by FPM of 1–1000-fold concentrations detected in school drinking water collected from a heavily contaminated area of the Huai River Basin. Thyroid-disrupting effects of FPM were evaluated by examining biomarkers of oxidative stress and thyroid function and tetraiodothyronine (T4) levels secreted by Nthy-ori 3-1 cells after FPM treatment. FPM activated the expression of NRF2, HO-1 (heme oxygenase 1), TPO, DIO I, and DIO II but inhibited NIS expression and increased the T4 level of thyrocytes, indicating that FPM can disrupt the function of human thyrocytes through oxidative pathways. Given the adverse impact of low FPM concentrations on human thyrocytes, supportive evidence from rodent studies, and the critical importance of thyroid hormones on development, the effects of FPM on the neurodevelopment and growth of children warrant priority attention.
AbstractList Fipronil is a broad-spectrum insecticide used for plants and poultry. Owing to its widespread use, fipronil and its metabolites (fipronil sulfone, fipronil desulfinyl, and fipronil sulfide), termed FPM, can be frequently detected in drinking water and food. Fipronil can affect the thyroid function of animals, but the effects of FPM on the human thyroid remain unclear. We employed human thyroid follicular epithelial Nthy-ori 3-1 cells to examine combined cytotoxic responses, thyroid-related functional proteins including the sodium-iodide symporter (NIS), thyroid peroxidase (TPO), deiodinases I-III (DIO I-III), and the nuclear factor erythroid-derived factor 2-related factor 2 (NRF2) pathway induced by FPM of 1-1000-fold concentrations detected in school drinking water collected from a heavily contaminated area of the Huai River Basin. Thyroid-disrupting effects of FPM were evaluated by examining biomarkers of oxidative stress and thyroid function and tetraiodothyronine (T4) levels secreted by Nthy-ori 3-1 cells after FPM treatment. FPM activated the expression of NRF2, HO-1 (heme oxygenase 1), TPO, DIO I, and DIO II but inhibited NIS expression and increased the T4 level of thyrocytes, indicating that FPM can disrupt the function of human thyrocytes through oxidative pathways. Given the adverse impact of low FPM concentrations on human thyrocytes, supportive evidence from rodent studies, and the critical importance of thyroid hormones on development, the effects of FPM on the neurodevelopment and growth of children warrant priority attention.
Author Crabbe, M. James C.
Qu, Weidong
Zhuang, Jianhui
Li, Jingguang
Chen, Dawei
Qiu, Meiyue
Zheng, Yuxin
Jiang, Zhiqiang
AuthorAffiliation Institute of Biomedical and Environmental Science & Technology
Key Laboratory of the Public Health Safety, Ministry of Education, Department of Environmental Health, School of Public Health
Department of Occupational and Environmental Health, School of Public Health
University of Bedfordshire
Qingdao University
Wolfson College
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Nthy-ori 3-1 cells
tetraiodothyronine
fipronil metabolites
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Snippet Fipronil is a broad-spectrum insecticide used for plants and poultry. Owing to its widespread use, fipronil and its metabolites (fipronil sulfone, fipronil...
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SubjectTerms Animals
Biomarkers
Cell Line
Cell lines
Child
Cytotoxicity
Disruption
Drinking water
Drinking Water - metabolism
Ecotoxicology and Public Health
Fipronil
Heme
Hormones
Humans
Insecticides
Iodide peroxidase
Iodides
Metabolites
NF-E2-Related Factor 2 - metabolism
NF-E2-Related Factor 2 - pharmacology
Oxidative stress
Oxygenase
Peroxidase
Pesticides
River basins
Thyrocytes
Thyroid
Thyroid Epithelial Cells
Thyroid gland
Thyroid Gland - metabolism
Thyroid hormones
Thyroxine
Title Thyroid-Disrupting Effects of Exposure to Fipronil and Its Metabolites from Drinking Water Based on Human Thyroid Follicular Epithelial Nthy-ori 3‑1 Cell Lines
URI http://dx.doi.org/10.1021/acs.est.2c08627
https://www.ncbi.nlm.nih.gov/pubmed/37022920
https://www.proquest.com/docview/2803522761
https://search.proquest.com/docview/2797150225
Volume 57
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