Associations of Prenatal Exposure to Per- and Polyfluoroalkyl Substances with the Neonatal Birth Size and Hormones in the Growth Hormone/Insulin-Like Growth Factor Axis

• Published in: Environmental science & technology Vol. 55; no. 17; pp. 11859 - 11873
• Main Authors: Luo, Dan, Wu, Weixiang, Pan, Yanan, Du, Bibai, Shen, Mingjie, Zeng, Lixi
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 07.09.2021
• Subjects: Alkanes - adverse effects; Alkanes - blood; Bayes Theorem; Bayesian analysis; Birth weight; China; Cord blood; Ecotoxicology and Public Health; Exposure; Female; Fetal Blood; Growth factors; Growth Hormone; Growth hormones; Hormones; Humans; Hydrocarbons, Fluorinated - adverse effects; Hydrocarbons, Fluorinated - blood; Infant, Newborn; Insulin; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Insulin-like growth factors; Mathematical models; Medical records; Neonates; Perfluoro compounds; Perfluoroalkyl & polyfluoroalkyl substances; Perfluorooctanoic acid; Ponderal index; Pregnancy; Prenatal experience; Prenatal Exposure Delayed Effects; Regression analysis; Regression models; Toxicity; Weight; China; joint effect; Bayesian kernel machine regression; fetal growth; GH/IGF axis; perfluorinated compounds

Toxicological data suggest a significant developmental toxicity of per- and polyfluoroalkyl substances (PFASs); however, evidence in humans remains inconclusive. Furthermore, the effects of prenatal exposure to PFASs on hormones in the growth hormone (GH)/insulin-like growth factor (IGF) axis of new...