Development of a Mass Spectrometry Imaging Method for Detecting and Mapping Graphene Oxide Nanoparticles in Rodent Tissues

• Published in: Journal of the American Society for Mass Spectrometry Vol. 31; no. 5; pp. 1025 - 1036
• Main Authors: Cazier, Hélène, Malgorn, Carole, Fresneau, Nathalie, Georgin, Dominique, Sallustrau, Antoine, Chollet, Céline, Tabet, Jean-Claude, Campidelli, Stéphane, Pinault, Mathieu, Mayne, Martine, Taran, Frédéric, Dive, Vincent, Junot, Christophe, Fenaille, François, Colsch, Benoit
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 06.05.2020
• Subjects: Animals; Chemical Sciences; Female; Graphite - administration & dosage; Graphite - analysis; Liver - chemistry; Lung - chemistry; Material chemistry; Mice; Mice, Inbred BALB C; Nanoparticles - analysis; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods; mass spectrometry imaging; laser desorption ionization mass spectrometry; nanoparticles; quantification; graphene

Graphene-based nanoparticles are continuously being developed for biomedical applications, and their use raises concerns about their environmental and biological impact. In the literature, some imaging techniques based on fluorescence and radioimaging have been used to explore their fate in vivo. He...