New Approach To Produce Monosized Polymer Microcapsules by the Solute Co-diffusion Method

This study introduces a new approach for producing highly monosized polymer microcapsules. The technique employs an impressive process in which the solute, dissolved freely in a solvent, is diffused uniformly into the preexisting monosized polymer particles in the form of a fine emulsion. The solven...

Full description

Saved in:
Bibliographic Details
Published inLangmuir Vol. 17; no. 18; pp. 5435 - 5439
Main Authors Kim, Jin-Woong, Cho, Sung-A, Kang, Hak-Hee, Han, Sang-Hoon, Chang, Ih-Seop, Lee, Ok-Sub, Suh, Kyung-Do
Format Journal Article
LanguageEnglish
Published American Chemical Society 04.09.2001
Online AccessGet full text

Cover

Abstract This study introduces a new approach for producing highly monosized polymer microcapsules. The technique employs an impressive process in which the solute, dissolved freely in a solvent, is diffused uniformly into the preexisting monosized polymer particles in the form of a fine emulsion. The solvent is then eliminated, resulting consequently in solute-loaded polymer microcapsules. We named it a solute co-diffusion method, SCM. The loading efficiency of the solute was predicted successfully by a thermodynamic equation. In the experiment, the indomethacin-loaded poly(methyl methacrylate) microparticles were produced via SCM. From our results, SCM is expected to expand significantly the drug-loading technology in related fields.
AbstractList This study introduces a new approach for producing highly monosized polymer microcapsules. The technique employs an impressive process in which the solute, dissolved freely in a solvent, is diffused uniformly into the preexisting monosized polymer particles in the form of a fine emulsion. The solvent is then eliminated, resulting consequently in solute-loaded polymer microcapsules. We named it a solute co-diffusion method, SCM. The loading efficiency of the solute was predicted successfully by a thermodynamic equation. In the experiment, the indomethacin-loaded poly(methyl methacrylate) microparticles were produced via SCM. From our results, SCM is expected to expand significantly the drug-loading technology in related fields.
Author Suh, Kyung-Do
Cho, Sung-A
Han, Sang-Hoon
Kang, Hak-Hee
Chang, Ih-Seop
Lee, Ok-Sub
Kim, Jin-Woong
Author_xml – sequence: 1
  givenname: Jin-Woong
  surname: Kim
  fullname: Kim, Jin-Woong
– sequence: 2
  givenname: Sung-A
  surname: Cho
  fullname: Cho, Sung-A
– sequence: 3
  givenname: Hak-Hee
  surname: Kang
  fullname: Kang, Hak-Hee
– sequence: 4
  givenname: Sang-Hoon
  surname: Han
  fullname: Han, Sang-Hoon
– sequence: 5
  givenname: Ih-Seop
  surname: Chang
  fullname: Chang, Ih-Seop
– sequence: 6
  givenname: Ok-Sub
  surname: Lee
  fullname: Lee, Ok-Sub
– sequence: 7
  givenname: Kyung-Do
  surname: Suh
  fullname: Suh, Kyung-Do
BookMark eNpt0DtPwzAUBWALFYm2MPAPvDAwBPxK0oxVxEu0paKRECyWsa_VlDSO7ERQfj1BRZ2Y7vLp6J4zQoPa1YDQOSVXlDB6XSlCaBILd4SGNGYkiicsHaAhSQWPUpHwEzQKYUMIybjIhuh1AZ942jTeKb3GhcNL70ynAc9d7UL5DQYvXbXbgsfzUnunVRO6CgJ-3-F2DXjlqq4FnLvIlNZ2oXQ1nkO7duYUHVtVBTj7u2NU3N4U-X00e7p7yKezSPGEthHTQGmilM0MN5mwMddWiFTTlGWGZExZYvoKMGHABRidKUu1ZZxoYqlSfIwu97H9cyF4sLLx5Vb5naRE_k4iD5P0NtrbMrTwdYDKf8gk5Wksi-VKFo-LPInfXuRz7y_2XukgN67zdV_kn9wfQV9yGw
CitedBy_id crossref_primary_10_1246_cl_2005_388
crossref_primary_10_1016_j_colsurfa_2005_09_030
crossref_primary_10_1002_marc_200500233
crossref_primary_10_1080_15421406_2011_653286
crossref_primary_10_1021_acs_analchem_8b05515
crossref_primary_10_1002_app_13095
crossref_primary_10_1002_pola_20082
crossref_primary_10_1007_s00396_005_1369_3
crossref_primary_10_1016_S0927_7757_02_00258_3
crossref_primary_10_1080_02678290412331286033
crossref_primary_10_1002_adem_200300338
crossref_primary_10_1016_j_eurpolymj_2007_02_033
crossref_primary_10_1039_C8RA00801A
crossref_primary_10_1016_j_jiec_2007_06_001
crossref_primary_10_1021_acs_jpcc_8b02546
crossref_primary_10_1021_acsami_8b02561
Cites_doi 10.1021/bk-1993-0520
10.1023/A:1015860531565
10.1016/0001-8686(80)87003-5
10.1016/0378-5173(92)90101-7
10.1002/macp.1978.021790323
10.1007/s003960050323
10.1016/0079-6700(92)90017-S
10.1002/1521-3927(20010201)22:4<257::AID-MARC257>3.0.CO;2-8
10.1016/0378-5173(90)90237-X
10.1002/(SICI)1097-4628(19960328)59:13<2009::AID-APP6>3.0.CO;2-L
10.1002/1521-3935(20010301)202:5<621::AID-MACP621>3.0.CO;2-K
10.1007/s003960050368
10.1007/978-94-009-1950-1
10.1002/(SICI)1097-4628(19960516)60:7<1025::AID-APP13>3.0.CO;2-#
10.1016/0095-8522(54)90040-9
10.1016/0378-5173(91)90225-D
10.1021/bk-2000-0752
10.1002/macp.1979.021800317
10.1007/s003960050561
10.1007/BF03258221
10.1002/pi.4990300409
10.1007/BF00657729
10.1016/0927-7757(95)03477-3
10.1002/pola.1990.080280314
10.1016/S0032-3861(99)00846-0
ContentType Journal Article
Copyright Copyright © 2001 American Chemical Society
Copyright_xml – notice: Copyright © 2001 American Chemical Society
DBID BSCLL
AAYXX
CITATION
DOI 10.1021/la001654o
DatabaseName Istex
CrossRef
DatabaseTitle CrossRef
DatabaseTitleList
DeliveryMethod fulltext_linktorsrc
Discipline Chemistry
EISSN 1520-5827
EndPage 5439
ExternalDocumentID 10_1021_la001654o
ark_67375_TPS_TKNC65ZW_R
d031525137
GroupedDBID -
.K2
02
186
4.4
53G
55A
5GY
5VS
7~N
AABXI
ABDEX
ABDTD
ABFLS
ABMVS
ABPTK
ABUCX
ACGFS
ACJ
ACNCT
ACS
AEESW
AENEX
AFEFF
AFFNX
ALMA_UNASSIGNED_HOLDINGS
ANTXH
AQSVZ
BAANH
CS3
DU5
EBS
ED
ED~
EJD
F5P
GNL
IH9
IHE
JG
JG~
K2
LG6
OHM
RNS
ROL
TN5
UI2
UPT
VF5
VG9
W1F
X
---
-~X
6TJ
AAHBH
ABJNI
ABQRX
ADHLV
AGXLV
AHGAQ
BSCLL
CUPRZ
GGK
YQT
~02
AAYXX
CITATION
ID FETCH-LOGICAL-a361t-2ce116aaf9d3d94f53cf447c1729d092af0d827e82e34edc9af1cf230c0f1aa3
IEDL.DBID ACS
ISSN 0743-7463
IngestDate Fri Aug 23 03:28:54 EDT 2024
Wed Oct 30 09:35:39 EDT 2024
Thu Feb 04 21:43:06 EST 2021
IsPeerReviewed true
IsScholarly true
Issue 18
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-a361t-2ce116aaf9d3d94f53cf447c1729d092af0d827e82e34edc9af1cf230c0f1aa3
Notes ark:/67375/TPS-TKNC65ZW-R
istex:555125AC064847749DD5CC513835B3165343DCF8
PageCount 5
ParticipantIDs crossref_primary_10_1021_la001654o
istex_primary_ark_67375_TPS_TKNC65ZW_R
acs_journals_10_1021_la001654o
ProviderPackageCode JG~
55A
AABXI
GNL
VF5
7~N
ACJ
VG9
W1F
ANTXH
ACS
AEESW
AFEFF
.K2
ABMVS
ABUCX
IH9
BAANH
AQSVZ
ED~
UI2
PublicationCentury 2000
PublicationDate 2001-09-04
PublicationDateYYYYMMDD 2001-09-04
PublicationDate_xml – month: 09
  year: 2001
  text: 2001-09-04
  day: 04
PublicationDecade 2000
PublicationTitle Langmuir
PublicationTitleAlternate Langmuir
PublicationYear 2001
Publisher American Chemical Society
Publisher_xml – name: American Chemical Society
References Ugelstad J. (la001654ob00026/la001654ob00026_1) 1979; 180
Flory J. P. (la001654ob00017/la001654ob00017_1) 1953
Sheu H. R. (la001654ob00013/la001654ob00013_1) 1990; 28
Morton M. (la001654ob00016/la001654ob00016_1) 1954; 9
El-Nokaly M. A. (la001654ob00002/la001654ob00002_1) 1993
Loftsson T. (la001654ob00005/la001654ob00005_1) 1992; 79
Kim J. W. (la001654ob00015/la001654ob00015_1) 2001; 202
Kim J. W. (la001654ob00014/la001654ob00014_1) 2000; 41
Okubo M. (la001654ob00029/la001654ob00029_1) 1993; 30
Donbrow D. (la001654ob00011/la001654ob00011_1) 1987
Omi S. (la001654ob00030/la001654ob00030_1) 1996; 109
Okubo M. (la001654ob00020/la001654ob00020_1) 1996; 60
Backkenfeld T. (la001654ob00007/la001654ob00007_1) 1991; 74
Kim J. W. (la001654ob00022/la001654ob00022_1) 1998; 276
Backkenfeld T. (la001654ob00008/la001654ob00008_1) 1990; 7
Candau F. (la001654ob00018/la001654ob00018_1) 1990
Okubo M. (la001654ob00028/la001654ob00028_1) 1992; 270
Thomson B. (la001654ob00012/la001654ob00012_1) 1996; 59
Ugelstad J. (la001654ob00027/la001654ob00027_1) 1980; 13
Loftsson T. (la001654ob00010/la001654ob00010_1) 1989; 1
Rainsford K. D. (la001654ob00006/la001654ob00006_1) 1990; 2
Park K. N. (la001654ob00003/la001654ob00003_1) 2000
Ugelstad J. (la001654ob00025/la001654ob00025_1) 1978; 179
Kim J. W. (la001654ob00021/la001654ob00021_1) 2001; 22
Ugelstad J. (la001654ob00019/la001654ob00019_1) 1992; 17
Kim J. W. (la001654ob00024/la001654ob00024_1) 2000; 278
Loftsson T. (la001654ob00004/la001654ob00004_1) 1990; 62
Kim J. W. (la001654ob00023/la001654ob00023_1) 1999; 277
Bettinetti G. P. (la001654ob00009/la001654ob00009_1) 1989; 44
Arshady R. (la001654ob00001/la001654ob00001_1) 1999
References_xml – volume-title: Polymeric Delivery Systems: Properties and Applications
  year: 1993
  ident: la001654ob00002/la001654ob00002_1
  doi: 10.1021/bk-1993-0520
  contributor:
    fullname: El-Nokaly M. A.
– volume: 7
  start-page: 484
  year: 1990
  ident: la001654ob00008/la001654ob00008_1
  publication-title: Pharm. Res.
  doi: 10.1023/A:1015860531565
  contributor:
    fullname: Backkenfeld T.
– volume: 13
  start-page: 101
  year: 1980
  ident: la001654ob00027/la001654ob00027_1
  publication-title: Adv. Colloid Interface Sci.
  doi: 10.1016/0001-8686(80)87003-5
  contributor:
    fullname: Ugelstad J.
– volume: 79
  start-page: 107
  year: 1992
  ident: la001654ob00005/la001654ob00005_1
  publication-title: Int. J. Pharm.
  doi: 10.1016/0378-5173(92)90101-7
  contributor:
    fullname: Loftsson T.
– volume: 179
  start-page: 815
  year: 1978
  ident: la001654ob00025/la001654ob00025_1
  publication-title: Makromol. Chem.
  doi: 10.1002/macp.1978.021790323
  contributor:
    fullname: Ugelstad J.
– volume: 276
  start-page: 870
  year: 1998
  ident: la001654ob00022/la001654ob00022_1
  publication-title: Colloid Polym. Sci.
  doi: 10.1007/s003960050323
  contributor:
    fullname: Kim J. W.
– volume: 17
  start-page: 87
  year: 1992
  ident: la001654ob00019/la001654ob00019_1
  publication-title: Prog. Polym. Sci.
  doi: 10.1016/0079-6700(92)90017-S
  contributor:
    fullname: Ugelstad J.
– volume: 22
  start-page: 257
  year: 2001
  ident: la001654ob00021/la001654ob00021_1
  publication-title: Macromol. Rapid Commun.
  doi: 10.1002/1521-3927(20010201)22:4<257::AID-MARC257>3.0.CO;2-8
  contributor:
    fullname: Kim J. W.
– volume: 44
  start-page: 196
  year: 1989
  ident: la001654ob00009/la001654ob00009_1
  publication-title: Farmaco
  contributor:
    fullname: Bettinetti G. P.
– volume: 62
  start-page: 243
  year: 1990
  ident: la001654ob00004/la001654ob00004_1
  publication-title: Int. J. Pharm.
  doi: 10.1016/0378-5173(90)90237-X
  contributor:
    fullname: Loftsson T.
– volume: 59
  start-page: 2009
  year: 1996
  ident: la001654ob00012/la001654ob00012_1
  publication-title: J. Appl. Polym. Sci.
  doi: 10.1002/(SICI)1097-4628(19960328)59:13<2009::AID-APP6>3.0.CO;2-L
  contributor:
    fullname: Thomson B.
– volume: 202
  start-page: 621
  year: 2001
  ident: la001654ob00015/la001654ob00015_1
  publication-title: Macromol. Chem. Phys.
  doi: 10.1002/1521-3935(20010301)202:5<621::AID-MACP621>3.0.CO;2-K
  contributor:
    fullname: Kim J. W.
– volume: 277
  start-page: 66
  year: 1999
  ident: la001654ob00023/la001654ob00023_1
  publication-title: Colloid Polym. Sci.
  doi: 10.1007/s003960050368
  contributor:
    fullname: Kim J. W.
– volume-title: Scientific Methods for the Study of Polymer Colloids and Their Applications
  year: 1990
  ident: la001654ob00018/la001654ob00018_1
  doi: 10.1007/978-94-009-1950-1
  contributor:
    fullname: Candau F.
– volume: 60
  start-page: 1025
  year: 1996
  ident: la001654ob00020/la001654ob00020_1
  publication-title: J. Appl. Polym. Sci.
  doi: 10.1002/(SICI)1097-4628(19960516)60:7<1025::AID-APP13>3.0.CO;2-#
  contributor:
    fullname: Okubo M.
– volume: 9
  start-page: 300
  year: 1954
  ident: la001654ob00016/la001654ob00016_1
  publication-title: J. Colloid Sci.
  doi: 10.1016/0095-8522(54)90040-9
  contributor:
    fullname: Morton M.
– volume: 74
  start-page: 85
  year: 1991
  ident: la001654ob00007/la001654ob00007_1
  publication-title: Int. J. Pharm.
  doi: 10.1016/0378-5173(91)90225-D
  contributor:
    fullname: Backkenfeld T.
– volume-title: Controlled Drug Delivery: Designing Technologies for the Future
  year: 2000
  ident: la001654ob00003/la001654ob00003_1
  doi: 10.1021/bk-2000-0752
  contributor:
    fullname: Park K. N.
– volume: 1
  start-page: 185
  year: 1989
  ident: la001654ob00010/la001654ob00010_1
  publication-title: Acta Pharm. Nord.
  contributor:
    fullname: Loftsson T.
– volume: 180
  start-page: 737
  year: 1979
  ident: la001654ob00026/la001654ob00026_1
  publication-title: Makromol. Chem.
  doi: 10.1002/macp.1979.021800317
  contributor:
    fullname: Ugelstad J.
– volume-title: Principles of Polymer Chemistry
  year: 1953
  ident: la001654ob00017/la001654ob00017_1
  contributor:
    fullname: Flory J. P.
– volume: 278
  start-page: 591
  year: 2000
  ident: la001654ob00024/la001654ob00024_1
  publication-title: Colloid Polym. Sci.
  doi: 10.1007/s003960050561
  contributor:
    fullname: Kim J. W.
– volume-title: Topics in Pharmaceutical Science
  year: 1987
  ident: la001654ob00011/la001654ob00011_1
  contributor:
    fullname: Donbrow D.
– volume: 2
  start-page: 3
  year: 1990
  ident: la001654ob00006/la001654ob00006_1
  publication-title: Drug Invest.
  doi: 10.1007/BF03258221
  contributor:
    fullname: Rainsford K. D.
– volume: 30
  start-page: 469
  year: 1993
  ident: la001654ob00029/la001654ob00029_1
  publication-title: Polym. Int.
  doi: 10.1002/pi.4990300409
  contributor:
    fullname: Okubo M.
– volume: 270
  start-page: 853
  year: 1992
  ident: la001654ob00028/la001654ob00028_1
  publication-title: Colloid Polym. Sci.
  doi: 10.1007/BF00657729
  contributor:
    fullname: Okubo M.
– volume: 109
  start-page: 97
  year: 1996
  ident: la001654ob00030/la001654ob00030_1
  publication-title: Colloid Surf., A
  doi: 10.1016/0927-7757(95)03477-3
  contributor:
    fullname: Omi S.
– volume: 28
  start-page: 629
  year: 1990
  ident: la001654ob00013/la001654ob00013_1
  publication-title: J. Polym. Sci., Part A: Polym. Chem.
  doi: 10.1002/pola.1990.080280314
  contributor:
    fullname: Sheu H. R.
– volume-title: Microspheres Microcapsules & Liposomes
  year: 1999
  ident: la001654ob00001/la001654ob00001_1
  contributor:
    fullname: Arshady R.
– volume: 41
  start-page: 6181
  year: 2000
  ident: la001654ob00014/la001654ob00014_1
  publication-title: Polymer
  doi: 10.1016/S0032-3861(99)00846-0
  contributor:
    fullname: Kim J. W.
SSID ssj0009349
Score 1.8098084
Snippet This study introduces a new approach for producing highly monosized polymer microcapsules. The technique employs an impressive process in which the solute,...
SourceID crossref
istex
acs
SourceType Aggregation Database
Publisher
StartPage 5435
Title New Approach To Produce Monosized Polymer Microcapsules by the Solute Co-diffusion Method
URI http://dx.doi.org/10.1021/la001654o
https://api.istex.fr/ark:/67375/TPS-TKNC65ZW-R/fulltext.pdf
Volume 17
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV1LT8JAEN4gHPTi24gPslHjrdjdbl9HUiVEAyFSI3pptvtIDEgNhUT49e62FDG-7tt0M7Oz883OzDcAXCg9O0Qi31A3JDZIrI6xRxk3uKdiDZMpgC91v3O747QeyG3f7pfA-S8ZfIyuhtTMWm6SNVDBrunpo9sIep_MulaOcTXXpkscq6APWv1Uux6WfnE9FS3F9xVf0twC10VHTl5CMqhPJ3Gdzb8TNP61zW2wucCSsJErfweUxGgXrAfFCLc98KSuMNhYsIbDMIHdjN9VQGXJSfoyFxx2k-HsVYxhWxfmMapi5qFIYTyDChjC7M1MwCAx9ByVqX5Yg-1s5PQ-CJs3YdAyFrMUDGo5aGJgJhByKJU-t7hPpG0xSYjLFH7xueljKk3uYVd4WFhEcOZTiZhU8QkzJaLUOgDlUTIShwAiKkybMURjpWUVl1NXEmVqDHPketTxqqCmZB0tTCGNsiw3RtFSQFVwVqghesspNX5adJkpaLmCjge6Bs21o7Dbi8K7TuDYz4_R_dF_vzsGG3ndmE4CnYDyZDwVpwpITOJadpA-AHtIwZg
link.rule.ids 315,783,787,2773,27089,27937,27938,57071,57121
linkProvider American Chemical Society
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3JTsMwELVYDnBhR-xYCHELxImzHauIqtBFFQSxXCLHi4RaGtS0Eu3XM3ZSNiHB3YmtmbHnjT3zBqFT0LNPFYksOCEdi2ZgxiHjwhIhxBo2B4CvdL1zu-M37uj1g_dQ0eToWhhYRAF_Kswj_ie7ALnoM9tU3uTzaNELwDFqGBTffhLsuiXU1ZSbAfXdGYvQ10-1B-LFNw-0qIX59sWl1FfL3kRmMSaTpHc-HmXnfPqDp_F_q11DKxWyxLXSFNbRnBxsoKV41tBtEz3CgYZrFYc4TnLcNWyvEsO-zovnqRS4m_cnL3KI2zpNjzOIoPuywNkEA0zE5gZN4ji3dFeVsb5mw23TgHoLJfXLJG5YVWcFi7k-GVkOl4T4jKlIuCKiynO5ojTggGYiYUcOU7YInUCGjnSpFDxiinAF0Qq3FWHM3UYLg3wgdxAmTNoe54RloHOI0lmgKGw87ggShMwPd9ERyCetNkaRmjdvh6QfAtpFJzNtpK8lwcZvg86Mnj5GsGFPZ6QFXpp0b9Ok2Yl97-k-vdn7a7pjtNRI2q20ddVp7qPlMqNMPw8doIXRcCwPAWKMsiNjW--hg8n4
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1ZT8MwDI6AScALN-IcEUK8FZo2vR6nwgSMjYkVcbxUaQ4JMVa0bhLw63GybhxCgve0sXzEdmJ_RugA5OxTRSILTkjHohmocci4sEQIuYbNIcBXut-52fLPbujFnXdXJoq6FwaIKOBPhXnE11b9IlSJMECOu8w23Tf5NKp4AXG0IdbizifIrjsKdzXsZkB9d4wk9PVT7YV48c0LVTRDX7-4lfoiupoQZKpJno6Gg-yIv__Aavw_xUtooYwwcW2kEstoSvZW0Fw8Huy2iu7hYMO1EkscJzluG9RXicG-8-LxXQrczrtvz7KPm7pcjzPIpLuywNkbhnARm5s0iePc0tNVhvq6DTfNIOo1lNRPk_jMKicsWMz1ycByuCTEZ0xFwhURVZ7LFaUBh6gmEnbkMGWL0Alk6EiXSsEjpghXkLVwWxHG3HU008t7cgNhwqTtcU5YBrKHbJ0FioIBckeQIGR-uImqwKO0NJAiNW_fDkknDNpE-2OJpC8joI3fFh0aWU1WsP6TrkwLvDRpd9Kk0Yp97-E2vd76a7s9NNs-qaeX563GNpofFZbpV6IdNDPoD-UuRBqDrGrU6wNH7cxy
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=New+Approach+To+Produce+Monosized+Polymer+Microcapsules+by+the+Solute+Co-diffusion+Method&rft.jtitle=Langmuir&rft.au=KIM%2C+Jin-Woong&rft.au=CHO%2C+Sung-A&rft.au=KANG%2C+Hak-Hee&rft.au=HAN%2C+Sang-Hoon&rft.date=2001-09-04&rft.pub=American+Chemical+Society&rft.issn=0743-7463&rft.eissn=1520-5827&rft.volume=17&rft.issue=18&rft.spage=5435&rft.epage=5439&rft_id=info:doi/10.1021%2Fla001654o&rft.externalDBID=n%2Fa&rft.externalDocID=ark_67375_TPS_TKNC65ZW_R
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0743-7463&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0743-7463&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0743-7463&client=summon