Isotope Dilution DNA Logic Circuits for Multiple Output and Absolute Quantification
DNA logic circuits have gained great success in the past, thanks to their distinct performance regarding the scalability and correctness of computation. However, there are still two challenges often considered for DNA logic circuit-based computation. First, the mainstream optical probes are often su...
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| Published in | Analytical chemistry (Washington) Vol. 97; no. 12; pp. 6670 - 6677 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
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United States
American Chemical Society
01.04.2025
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| Abstract | DNA logic circuits have gained great success in the past, thanks to their distinct performance regarding the scalability and correctness of computation. However, there are still two challenges often considered for DNA logic circuit-based computation. First, the mainstream optical probes are often subject to spectral overlapping interference for complex multitask analysis and outputs. Second, absolute quantification results traceable to the primary international system of units are mission impossible, especially for interlaboratory comparisons and quality assurances. Herein, we constructed DNA logic circuits encoded with lanthanide isotopes and decoded by elemental mass spectrometry. The 155Gd-enriched isotope and 145Nd-enriched isotope were incorporated in the DNA logic circuits for the isotope dilution-based absolute quantification of microRNAs. The proposed isotopic DNA logic circuits greatly enhance the multiplexity and computation accuracy, which poses a great potential for cancer biomarker-related diagnosis. |
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| AbstractList | DNA logic circuits have gained great success in the past, thanks to their distinct performance regarding the scalability and correctness of computation. However, there are still two challenges often considered for DNA logic circuit-based computation. First, the mainstream optical probes are often subject to spectral overlapping interference for complex multitask analysis and outputs. Second, absolute quantification results traceable to the primary international system of units are mission impossible, especially for interlaboratory comparisons and quality assurances. Herein, we constructed DNA logic circuits encoded with lanthanide isotopes and decoded by elemental mass spectrometry. The
Gd-enriched isotope and
Nd-enriched isotope were incorporated in the DNA logic circuits for the isotope dilution-based absolute quantification of microRNAs. The proposed isotopic DNA logic circuits greatly enhance the multiplexity and computation accuracy, which poses a great potential for cancer biomarker-related diagnosis. DNA logic circuits have gained great success in the past, thanks to their distinct performance regarding the scalability and correctness of computation. However, there are still two challenges often considered for DNA logic circuit-based computation. First, the mainstream optical probes are often subject to spectral overlapping interference for complex multitask analysis and outputs. Second, absolute quantification results traceable to the primary international system of units are mission impossible, especially for interlaboratory comparisons and quality assurances. Herein, we constructed DNA logic circuits encoded with lanthanide isotopes and decoded by elemental mass spectrometry. The 155Gd-enriched isotope and 145Nd-enriched isotope were incorporated in the DNA logic circuits for the isotope dilution-based absolute quantification of microRNAs. The proposed isotopic DNA logic circuits greatly enhance the multiplexity and computation accuracy, which poses a great potential for cancer biomarker-related diagnosis.DNA logic circuits have gained great success in the past, thanks to their distinct performance regarding the scalability and correctness of computation. However, there are still two challenges often considered for DNA logic circuit-based computation. First, the mainstream optical probes are often subject to spectral overlapping interference for complex multitask analysis and outputs. Second, absolute quantification results traceable to the primary international system of units are mission impossible, especially for interlaboratory comparisons and quality assurances. Herein, we constructed DNA logic circuits encoded with lanthanide isotopes and decoded by elemental mass spectrometry. The 155Gd-enriched isotope and 145Nd-enriched isotope were incorporated in the DNA logic circuits for the isotope dilution-based absolute quantification of microRNAs. The proposed isotopic DNA logic circuits greatly enhance the multiplexity and computation accuracy, which poses a great potential for cancer biomarker-related diagnosis. DNA logic circuits have gained great success in the past, thanks to their distinct performance regarding the scalability and correctness of computation. However, there are still two challenges often considered for DNA logic circuit-based computation. First, the mainstream optical probes are often subject to spectral overlapping interference for complex multitask analysis and outputs. Second, absolute quantification results traceable to the primary international system of units are mission impossible, especially for interlaboratory comparisons and quality assurances. Herein, we constructed DNA logic circuits encoded with lanthanide isotopes and decoded by elemental mass spectrometry. The 155Gd-enriched isotope and 145Nd-enriched isotope were incorporated in the DNA logic circuits for the isotope dilution-based absolute quantification of microRNAs. The proposed isotopic DNA logic circuits greatly enhance the multiplexity and computation accuracy, which poses a great potential for cancer biomarker-related diagnosis. DNA logic circuits have gained great success in the past, thanks to their distinct performance regarding the scalability and correctness of computation. However, there are still two challenges often considered for DNA logic circuit-based computation. First, the mainstream optical probes are often subject to spectral overlapping interference for complex multitask analysis and outputs. Second, absolute quantification results traceable to the primary international system of units are mission impossible, especially for interlaboratory comparisons and quality assurances. Herein, we constructed DNA logic circuits encoded with lanthanide isotopes and decoded by elemental mass spectrometry. The ¹⁵⁵Gd-enriched isotope and ¹⁴⁵Nd-enriched isotope were incorporated in the DNA logic circuits for the isotope dilution-based absolute quantification of microRNAs. The proposed isotopic DNA logic circuits greatly enhance the multiplexity and computation accuracy, which poses a great potential for cancer biomarker-related diagnosis. |
| Author | Liu, Rui Li, Ziyan Wei, Chao Lv, Yi Zhu, Yiyan Li, Yan |
| AuthorAffiliation | Key Laboratory of Green Chemistry & Technology, College of Chemistry Key Laboratory of Green Chemistry & Technology, Analytical & Testing Center |
| AuthorAffiliation_xml | – name: Key Laboratory of Green Chemistry & Technology, Analytical & Testing Center – name: Key Laboratory of Green Chemistry & Technology, College of Chemistry |
| Author_xml | – sequence: 1 givenname: Yiyan surname: Zhu fullname: Zhu, Yiyan organization: Key Laboratory of Green Chemistry & Technology, College of Chemistry – sequence: 2 givenname: Chao surname: Wei fullname: Wei, Chao – sequence: 3 givenname: Ziyan surname: Li fullname: Li, Ziyan organization: Key Laboratory of Green Chemistry & Technology, Analytical & Testing Center – sequence: 4 givenname: Yan surname: Li fullname: Li, Yan organization: Key Laboratory of Green Chemistry & Technology, College of Chemistry – sequence: 5 givenname: Rui orcidid: 0000-0001-9928-5373 surname: Liu fullname: Liu, Rui email: liur@scu.edu.cn organization: Key Laboratory of Green Chemistry & Technology, College of Chemistry – sequence: 6 givenname: Yi orcidid: 0000-0002-7104-2414 surname: Lv fullname: Lv, Yi email: lvy@scu.edu.cn organization: Key Laboratory of Green Chemistry & Technology, Analytical & Testing Center |
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| Cites_doi | 10.1016/j.genrep.2019.100398 10.1016/j.trac.2022.116710 10.1126/science.1198704 10.1021/acs.analchem.3c02231 10.1038/nm.3488 10.1021/acsnano.3c12000 10.1021/acs.analchem.3c05915 10.1016/j.cclet.2022.04.019 10.1038/s41565-019-0544-5 10.1021/acsami.2c22741 10.1038/s41586-023-06484-9 10.1038/s41570-024-00576-4 10.1016/j.nantod.2024.102320 10.1021/acs.jpclett.8b01944 10.1039/D2SC06601G 10.1002/anie.202307025 10.1021/acs.analchem.3c02403 10.1016/j.talanta.2017.09.031 10.1039/D3SC01162C 10.1002/anie.201108277 10.1021/acs.nanolett.3c03265 10.1038/s41596-018-0016-7 10.3892/ijmm.2012.1021 10.1002/anie.201206903 10.1021/acs.analchem.2c03367 10.1021/acs.analchem.0c01775 10.1007/s41664-023-00284-w 10.1016/j.trac.2017.05.008 10.1039/C7CC08052B 10.1016/j.mtchem.2019.04.005 10.1021/jacs.2c04325 10.1126/science.1200520 10.1021/acs.accounts.5b00509 10.1038/s41467-022-32526-3 10.1021/acs.analchem.3c00152 10.1002/anie.201101087 10.1002/anie.202103993 10.1002/advs.202400011 10.1021/acs.analchem.1c04557 10.1039/D3SC01960H 10.1021/acsnano.3c04777 10.1016/j.snb.2019.127545 10.1021/jacs.4c13706 10.1021/acs.analchem.8b01798 10.1021/jacs.2c09359 10.1093/nar/gkae017 10.3390/ijms20194940 10.1021/acs.analchem.2c04171 10.1002/smll.202207736 10.1039/C8SC03305F 10.1021/acs.analchem.1c04347 10.1021/acs.est.2c00964 10.1021/jacs.2c03258 10.1021/acs.analchem.4c00021 10.1021/acs.analchem.3c03553 10.1021/acs.analchem.3c04807 10.46770/AS.2023.285 10.1016/j.bios.2023.115084 10.1016/j.snb.2023.134063 |
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| References | ref9/cit9 ref45/cit45 ref3/cit3 ref27/cit27 ref56/cit56 ref16/cit16 ref52/cit52 ref23/cit23 ref8/cit8 ref31/cit31 ref59/cit59 ref2/cit2 ref34/cit34 ref37/cit37 ref20/cit20 ref48/cit48 ref17/cit17 ref10/cit10 ref35/cit35 ref53/cit53 ref19/cit19 ref21/cit21 ref42/cit42 ref46/cit46 ref49/cit49 ref13/cit13 ref24/cit24 ref38/cit38 ref50/cit50 ref54/cit54 ref6/cit6 ref36/cit36 ref18/cit18 ref11/cit11 ref25/cit25 ref29/cit29 ref32/cit32 ref39/cit39 ref14/cit14 ref57/cit57 ref5/cit5 ref51/cit51 ref43/cit43 ref28/cit28 ref40/cit40 ref26/cit26 ref55/cit55 ref12/cit12 ref15/cit15 ref41/cit41 ref58/cit58 ref22/cit22 ref33/cit33 ref4/cit4 ref30/cit30 ref47/cit47 ref1/cit1 ref44/cit44 ref7/cit7 |
| References_xml | – ident: ref54/cit54 doi: 10.1016/j.genrep.2019.100398 – ident: ref39/cit39 doi: 10.1016/j.trac.2022.116710 – ident: ref45/cit45 doi: 10.1126/science.1198704 – ident: ref49/cit49 doi: 10.1021/acs.analchem.3c02231 – ident: ref33/cit33 doi: 10.1038/nm.3488 – ident: ref6/cit6 doi: 10.1021/acsnano.3c12000 – ident: ref30/cit30 doi: 10.1021/acs.analchem.3c05915 – ident: ref58/cit58 doi: 10.1016/j.cclet.2022.04.019 – ident: ref16/cit16 doi: 10.1038/s41565-019-0544-5 – ident: ref57/cit57 doi: 10.1021/acsami.2c22741 – ident: ref5/cit5 doi: 10.1038/s41586-023-06484-9 – ident: ref1/cit1 doi: 10.1038/s41570-024-00576-4 – ident: ref4/cit4 doi: 10.1016/j.nantod.2024.102320 – ident: ref25/cit25 doi: 10.1021/acs.jpclett.8b01944 – ident: ref20/cit20 doi: 10.1039/D2SC06601G – ident: ref7/cit7 doi: 10.1002/anie.202307025 – ident: ref21/cit21 doi: 10.1021/acs.analchem.3c02403 – ident: ref59/cit59 doi: 10.1016/j.talanta.2017.09.031 – ident: ref11/cit11 doi: 10.1039/D3SC01162C – ident: ref43/cit43 doi: 10.1002/anie.201108277 – ident: ref19/cit19 doi: 10.1021/acs.nanolett.3c03265 – ident: ref24/cit24 doi: 10.1038/s41596-018-0016-7 – ident: ref55/cit55 doi: 10.3892/ijmm.2012.1021 – ident: ref44/cit44 doi: 10.1002/anie.201206903 – ident: ref35/cit35 doi: 10.1021/acs.analchem.2c03367 – ident: ref41/cit41 doi: 10.1021/acs.analchem.0c01775 – ident: ref15/cit15 doi: 10.1007/s41664-023-00284-w – ident: ref34/cit34 doi: 10.1016/j.trac.2017.05.008 – ident: ref32/cit32 doi: 10.1039/C7CC08052B – ident: ref50/cit50 doi: 10.1016/j.mtchem.2019.04.005 – ident: ref10/cit10 doi: 10.1021/jacs.2c04325 – ident: ref8/cit8 doi: 10.1126/science.1200520 – ident: ref31/cit31 doi: 10.1021/acs.accounts.5b00509 – ident: ref23/cit23 doi: 10.1038/s41467-022-32526-3 – ident: ref42/cit42 doi: 10.1021/acs.analchem.3c00152 – ident: ref28/cit28 doi: 10.1002/anie.201101087 – ident: ref13/cit13 doi: 10.1002/anie.202103993 – ident: ref2/cit2 doi: 10.1002/advs.202400011 – ident: ref27/cit27 doi: 10.1021/acs.analchem.1c04557 – ident: ref26/cit26 doi: 10.1039/D3SC01960H – ident: ref22/cit22 doi: 10.1021/acsnano.3c04777 – ident: ref52/cit52 doi: 10.1016/j.snb.2019.127545 – ident: ref36/cit36 doi: 10.1021/jacs.4c13706 – ident: ref51/cit51 doi: 10.1021/acs.analchem.8b01798 – ident: ref3/cit3 doi: 10.1021/jacs.2c09359 – ident: ref47/cit47 doi: 10.1093/nar/gkae017 – ident: ref48/cit48 doi: 10.3390/ijms20194940 – ident: ref56/cit56 doi: 10.1021/acs.analchem.2c04171 – ident: ref12/cit12 doi: 10.1002/smll.202207736 – ident: ref46/cit46 doi: 10.1039/C8SC03305F – ident: ref17/cit17 doi: 10.1021/acs.analchem.1c04347 – ident: ref40/cit40 doi: 10.1021/acs.est.2c00964 – ident: ref9/cit9 doi: 10.1021/jacs.2c03258 – ident: ref37/cit37 doi: 10.1021/acs.analchem.4c00021 – ident: ref38/cit38 doi: 10.1021/acs.analchem.3c03553 – ident: ref14/cit14 doi: 10.1021/acs.analchem.3c04807 – ident: ref29/cit29 doi: 10.46770/AS.2023.285 – ident: ref53/cit53 doi: 10.1016/j.bios.2023.115084 – ident: ref18/cit18 doi: 10.1016/j.snb.2023.134063 |
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| SubjectTerms | analytical chemistry Biomarkers Circuits Computation Computers, Molecular Deoxyribonucleic acid Dilution DNA DNA - chemistry DNA probes Gadolinium isotopes Humans International System of Units isotope dilution technique Isotopes Isotopes - chemistry lanthanides Lanthanoid Series Elements - chemistry Logic circuits Mass Spectrometry Mass spectroscopy microRNA MicroRNAs - analysis miRNA |
| Title | Isotope Dilution DNA Logic Circuits for Multiple Output and Absolute Quantification |
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