Bacterial Derived Carbohydrates Bind Cyr1 and Trigger Hyphal Growth in Candida albicans

• Published in: ACS infectious diseases Vol. 4; no. 1; pp. 53 - 58
• Main Authors: Burch, Jason M, Mashayekh, Siavash, Wykoff, Dennis D, Grimes, Catherine L
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 12.01.2018
• Subjects: Bacteria - metabolism; Candida albicans - physiology; Carbohydrate Metabolism; Carbohydrates; Hyphae - growth & development; Hyphae - metabolism; Letter; Mitochondrial Proteins - metabolism; Protein Binding; peptidoglycan; leucine-rich-repeat domain; hyphae formation; anthracycline; C. albicans

The dimorphic yeast Candida albicans is the most common pathogenic fungus found in humans. While this species is normally commensal, a morphological switch from budding yeast to filamentous hyphae allows the fungi to invade epithelial cells and cause infections. The phenotypic change is controlled b...