Optimization of Productivity and Thermodynamic Performance of Metabolic Pathways

• Published in: Industrial & engineering chemistry research Vol. 47; no. 15; pp. 5669 - 5679
• Main Authors: Xu, Mian, Smith, Robin, Sadhukhan, Jhuma
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 06.08.2008
• Subjects: Applied sciences; Chemical engineering; Escherichia coli; Exact sciences and technology; General Research; Optimization

In this contribution, a novel optimization strategy has been presented that combines the metabolic flux analysis and pathway identification with the thermodynamic analysis of cellular metabolic systems. First, an optimal metabolic flux distribution among elementary pathways is identified by LP optim...