Association of Intensive vs Standard Blood Pressure Control With Cerebral Blood Flow: Secondary Analysis of the SPRINT MIND Randomized Clinical Trial

• Published in: Archives of neurology (Chicago) Vol. 79; no. 4; p. 380
• Main Authors: Dolui, Sudipto, Detre, John A, Gaussoin, Sarah A, Herrick, Jennifer S, Wang, Danny J J, Tamura, Manjula Kurella, Cho, Monique E, Haley, William E, Launer, Lenore J, Punzi, Henry A, Rastogi, Anjay, Still, Carolyn H, Weiner, Daniel E, Wright, Jr, Jackson T, Williamson, Jeff D, Wright, Clinton B, Bryan, R Nick, Bress, Adam P, Pajewski, Nicholas M, Nasrallah, Ilya M
• Format: Journal Article
• Language: English
• Published: United States American Medical Association 01.04.2022
• Subjects: Aged; Antihypertensive Agents - pharmacology; Antihypertensive Agents - therapeutic use; Antihypertensives; Blood flow; Blood pressure; Blood Pressure - physiology; Brain; Cardiovascular disease; Cardiovascular Diseases; Cerebral blood flow; Cerebrovascular Circulation; Clinical trials; Cognitive ability; Dementia disorders; Diabetes mellitus; Female; Health risks; Health services; Humans; Hypertension; Hypertension - complications; Hypertension - diagnostic imaging; Hypertension - drug therapy; Hypotension; Kidney diseases; Magnetic resonance imaging; Medical imaging; Neuroimaging; Perfusion; Randomization; Secondary analysis; Subgroups; Substantia alba; Substantia grisea

Antihypertensive treatments benefit cerebrovascular health and cognitive function in patients with hypertension, but it is uncertain whether an intensive blood pressure target leads to potentially harmful cerebral hypoperfusion. To investigate the association of intensive systolic blood pressure (SB...