Patient-Derived Organoid Model in the Prediction of Chemotherapeutic Drug Response in Colorectal Cancer

• Published in: ACS biomaterials science & engineering Vol. 8; no. 8; pp. 3515 - 3525
• Main Authors: Hao, Minglu, Cao, Zhipeng, Wang, Zhiwei, Xin, Jianjun, Kong, Biao, Xu, Jing, Zhang, Lei, Chen, Pu
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 08.08.2022
• Subjects: Tissue Engineering and Regenerative Medicine; patient-derived organoid xenografts; colorectal cancer; drug screening; patient-derived organoid

As an emerging technology in precision medicine, the patient-derived organoid (PDO) technology has been indicated to provide novel modalities to judge the sensitivity of individual tumors to cancer drugs. In this work, an in vitro model of colorectal cancer (CRC) was established using the PDO cultur...